Determination of captopril in blood and urine by high-performance liquid chromatography.

Kawahara, Yukinori; Hisaoka, Masafumi; Yamazaki, Yasushi; Inage, Akiko; Morioka, Tadashi

doi:10.1248/cpb.29.150

Cited by 70 publications

(19 citation statements)

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“…The method used derived from that initially developed by Kawahara et al (1981) has previously been described (Richer et al, 1984). In brief, whole free form of unchanged captopril was trapped with p-BPB, which was used as a coupling reagent for the thiol function, thus ensuring its stability, and the addition product was evaluated by high pressure liquid chromatography (h.p.l.c.).…”

Section: Methodsmentioning

confidence: 99%

Influence of chronic renal failure on captopril pharmacokinetics and clinical and biological effects in hypertensive patients.

Jf¹,

Chaignon²,

Richer³

et al. 1984

Brit J Clinical Pharma

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The pharmacokinetic parameters of unchanged plasma captopril and the kinetics of the drug effects on plasma converting enzyme activity (PCEA), plasma renin activity (PRA), plasma aldosterone (PA) and mean blood pressure (MBP) were studied over 24 h after oral administration in three groups of hypertensive patients: with normal renal function (group 1, plasma creatinine less than 110 mumol/l, n = 10), with moderate chronic renal failure (group 2, 135 less than plasma creatinine less than 450 mumol/l, n = 10) and with severe chronic renal failure (group 3, plasma creatinine greater than 500 mumol/l, n = 10). Renal impairment had no effect on plasma captopril Cmax, CLtot and relative bioavailability (AUC). In contrast, captopril kel decreased while T1/2 increased progressively from group 1 to group 3. PCEA blockade (T1/2 and AUC) was increased significantly and proportionally to the degree of renal impairment. However, there were no differences between the three groups regarding captopril‐induced modifications of PRA and PA. Although the maximal reduction in MBP was identical in the three groups, the overall antihypertensive effect (AUC) of captopril increased significantly and progressively from group 1 to group 3, especially in duration. There was no correlation between basal plasma creatinine values and unchanged captopril relative bioavailability (AUC) and between unchanged captopril relative bioavailability (AUC) and the drug effects (AUC) on PCEA, PRA, PA and MBP. However there was a correlation between basal plasma creatinine values and plasma captopril T1/2, PCEA blockade (AUC) and overall antihypertensive effect (AUC). The apparent discrepancy between the lack of effects of chronic renal failure on plasma unchanged captopril bioavailability and its potentiating effects on PCEA blockade and MBP reduction may be accounted for by the renal impairment‐induced accumulation of captopril metabolites.

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Section: Methodsmentioning

confidence: 99%

Influence of chronic renal failure on captopril pharmacokinetics and clinical and biological effects in hypertensive patients.

Jf¹,

Chaignon²,

Richer³

et al. 1984

Brit J Clinical Pharma

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“…Giddings described a theoretical consideration in 1965 for chromatograms of reversible isomers, 1 and several chromatograms of reversible isomers have been reported, such as sugars, 2 proline peptides, [3][4][5] immunosuppressive drugs (cyclosporine derivatives, tacrolimus and rapamycin), [6][7][8] 3-hydroxybenzodiazepines, 9 and some angiotensin-converting enzyme inhibitors. [10][11][12][13] These compounds consist of two isomers that are converting to each other. We report here on the liquid chromatographic behavior of a compound that exists in three reversible isomers.…”

Section: Introductionmentioning

confidence: 99%

HPLC Profile of Captopril Disulfide That Undergoes Reversible cis-trans Conversion among Three Isomers

Nishikawa¹,

Abe²,

Sudo³

et al. 2004

ANAL. SCI.

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Peculiarly shaped chromatograms of some compounds that consist of two reversible isomers have been reported. Those of a compound that consists of three reversible isomers are described here. Because disulfide of captopril has two cistrans convertible bonds, it exists in three forms of cis-cis, cis-trans and trans-trans isomers. The disulfide has produced various HPLC-UV profiles under various conditions, such as three split peaks, three peaks with bridging plateaus and one broad peak. The effect of the column temperature and the eluent flow rate on the profile was investigated and explained by interconversion among three isomers. A profile analysis could provide some kinetic constants of this reaction.

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“…These equilibria and the conditions under which they arise have to be considered in the development of the technique, especially with respect to storage and sample preparation. One way of reducing the possibility of these reactions occurring in situ is to add Nethylmaleimide (h, NEM) to the biological sample once collected (23,26,27,(29)(30)(31)(32)(33).…”

Section: Methods O F Analysismentioning

confidence: 99%

“…As captopril does not possess a suitable chromophore to make it amenable to either ultraviolet or fluorescent detection with HPLC, one approach has been to utilize the maleimide derivatization step to form a derivative which can be separated by HPLC, and measured with ultraviolet (26,27), fluorescence (25) or electrochemical (29) detection. Some of the methods are multi-step, i.e.…”

Section: Methods O F Analysismentioning

confidence: 99%

Recent Advances in Pharmaceutical Chemistry—angiotensin-Converting Enzyme Inhibitors

Skellern

1989

J Clin Pharm Ther

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Determination of captopril in blood and urine by high-performance liquid chromatography.

Cited by 70 publications

References 0 publications

Influence of chronic renal failure on captopril pharmacokinetics and clinical and biological effects in hypertensive patients.

Influence of chronic renal failure on captopril pharmacokinetics and clinical and biological effects in hypertensive patients.

HPLC Profile of Captopril Disulfide That Undergoes Reversible cis-trans Conversion among Three Isomers

Recent Advances in Pharmaceutical Chemistry—angiotensin-Converting Enzyme Inhibitors

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