Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development

Mirza, Tahseen; Tan, Henry S.I.

doi:10.1016/s0731-7085(00)00462-3

Cited by 62 publications

(21 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our suggestions are presented in Table 1. It is well known that even if two columns are formally of the same type their performance can differ [145]. Additionally, it may be necessary to investigate robustness related to change of the instrument or some of its components.…”

Section: Experimental Design Of Ruggedness/robustness T Experimental mentioning

confidence: 99%

Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I

Kruve

Rebane

Kipper

et al. 2015

Analytica Chimica Acta

246

145

View full text Add to dashboard Cite

This is the part I of a tutorial review intending to give an overview of the state of the art of method validation in liquid chromatography mass spectrometry (LC-MS) and discuss specific issues that arise with MS (and MS/MS) detection in LC (as opposed to the "conventional" detectors). The Part I briefly introduces the principles of operation of LC-MS (emphasizing the aspects important from the validation point of view, in particular the ionization process and ionization suppression/enhancement); reviews the main validation guideline documents and discusses in detail the following performance parameters: selectivity/specificity/identity, ruggedness/robustness, limit of detection, limit of quantification, decision limit and detection capability. With every method performance characteristic its essence and terminology are addressed, the current status of treating it is reviewed and recommendations are given, how to determine it, specifically in the case of LC-MS methods.

show abstract

Section: Experimental Design Of Ruggedness/robustness T Experimental mentioning

confidence: 99%

Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I

Kruve

Rebane

Kipper

et al. 2015

Analytica Chimica Acta

246

145

View full text Add to dashboard Cite

show abstract

“…E-mail: basavaiahk@yahoo.co.in available for determining CPT in its dosage forms. Presently, the most widely used technique for its determination is highperformance liquid-chromatography [5][6][7][8][9][10][11][12][13][14]. Though the technique is rapid and sensitive, quite often it involves precolumn derivatization [6][7][8][9][10] and multiple extraction steps.…”

Section: Introductionmentioning

confidence: 99%

Argentimetric assay of captopril in bulk drug and in tablets

Basavaiah

Nagegowda

2004

JICS

View full text Add to dashboard Cite

Three simple, selective and cost-effective procedures for the determination of captopril in bulk drug and in tablets are described. All the procedures make use of silver nitrate as a reagent and involve titrimetry and spectrophotometry as measurement techniques. In titrimetry (Method A), the aqueous solution of the drug is titrated directly with the standard silver nitrate solution to a potassium chromate end-point. In one spectrophotometric method (Method B), the sample solution is treated with excess of silver nitrate and a known amount of methyl orange and the increase in absorbance at 520 nm, caused by a decrease in pH due to release of nitric acid, is measured and related to drug concentration. The other spectrophotometric method (Method C) involves the addition of a measured excess of silver nitrate to the sample solution followed by the determination of residual silver ion by an ion-associate complex formation reaction involving eosin and 1,10-phenanthroline. The decrease in absorbance at 550 nm, which corresponds to Ag + reacted with the drug, is measured and is found to be linearly related to drug concentration. All experimental variables involved in the methods were investigated and optimized. Stoichiometry of the reaction that forms the basis for titrimetry is found. Method A is applicable in the range of 1.0-20.0 mg of drug while methods B and C can be conveniently used in the concentration ranges of 2.5-50.0 and 0.25-4.0 g ml -1 , respectively. Several optical characteristics such as molar absorptivity, Sandell sensitivity, limits of detection and quantification, and correlation coefficient were calculated. The methods were applied to the analysis of tablets containing captopril. Statistical treatment of the results indicates that the procedures are precise and accurate. The excipients used as additives in tablets did not interfere in the proposed procedures as revealed by the recovery studies.

show abstract

“…CP is an angiotensin-converting enzyme (ACE) that was used for the treatment of hypertension and some types of congestive heart failure due to its exquisite mechanism of action and for the revolutionary expansion process [3]. CP is metabolized essentially to disulfide conjugates with other sulfhydryl containing molecules.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a manganese titanate nanosensor: Application in electrochemical studies of captopril in the presence of para-aminobenzoic acid

Ghoreishi

Karamali

Khoobi

et al. 2015

Analytical Biochemistry

View full text Add to dashboard Cite

Determination of captopril in pharmaceutical tablets by anion-exchange HPLC using indirect photometric detection; a study in systematic method development

Cited by 62 publications

References 9 publications

Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I

Tutorial review on validation of liquid chromatography–mass spectrometry methods: Part I

Argentimetric assay of captopril in bulk drug and in tablets

Preparation of a manganese titanate nanosensor: Application in electrochemical studies of captopril in the presence of para-aminobenzoic acid

Contact Info

Product

Resources

About