Determination of Carvacrol and Thymol in Honey by Using a Simple and Efficient Headspace-Gas Chromatography-Mass Spectrometry Method

Bernal, José; Nozal, Marı́a J.; Ares, Ana M.

doi:10.1007/s12161-020-01833-0

Cited by 11 publications

(1 citation statement)

References 25 publications

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“…Thymol and carvacrol are volatile compounds. Therefore, gas chromatography with a flame ionization detector [ 14 , 15 ] or mass-spectrometric detection [ 16 , 17 , 18 , 19 , 20 ] is successfully applied for their determination in plant materials [ 14 , 20 ], biosamples [ 16 ], and foodstuffs [ 15 , 16 , 17 , 18 , 19 ]. High-performance liquid chromatography with UV- [ 21 , 22 , 23 , 24 , 25 , 26 ] and fluorimetric detection [ 27 ] has been widely applied in the analysis of liquid samples such as essential oils, medicinal plant extracts, and honey.…”

Section: Introductionmentioning

confidence: 99%

Electrode Based on the MWCNTs and Electropolymerized Thymolphthalein for the Voltammetric Determination of Total Isopropylmethylphenols in Spices

Chernousova

Ziyatdinova

2023

Micromachines

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Isopropylmethylphenols, namely thymol and carvacrol, are natural phenolic monoterpenoids with a wide spectrum of bioactivity making them applicable in the cosmetic, pharmaceutical, and food industry. The dose-dependent antioxidant properties of isopropylmethylphenols require their quantification in real samples. Glassy carbon electrode (GCE) modified with multi-walled carbon nanotubes (MWCNTs) and electropolymerized thymolphthalein has been developed for the sensitive quantification of isopropylmethylphenols. Conditions of thymolphthalein electropolymerization (monomer concentration, number of cycles, and electrolysis parameters) providing the best response to thymol have been found. Scanning electron microscopy and electrochemical methods confirm the effectivity of the electrode developed. The linear dynamic ranges of 0.050–25 and 25–100 µM for thymol and 0.10–10 and 10–100 µM for carvacrol with detection limits of 0.037 and 0.063 µM, respectively, have been achieved in differential pulse mode in Britton–Robinson buffer pH 2.0. The selectivity of the isopropylmethylphenols response in the presence of typical interferences (inorganic ions, saccharides, ascorbic acid) and other phenolics (caffeic, chlorogenic, gallic and rosmarinic acids, and quercetin) is a significant advantage over other electrochemical methods. The electrode has been used in the analysis of oregano and thyme spices. Total isopropylmethylphenols contents have been evaluated after a single sonication-assisted extraction with methanol.

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