Determination of cerebral blood flow velocity and microembolic signals in essential thrombocytosis by transcranial doppler ultrasonography

Transcranial Doppler Findings in Myeloproliferative Diseases (Polycythemia Vera and Essential Thrombocytosis): A Systematic Review

“…Elevated hematocrit and hemoglobin values in all 22 PV cases (Del Sette et al, 1995;Segura et al, 2000;Fiermonte et al, 1993) and an elevated platelet value in one ET patient have improved to normal levels after treatment (Blaser et al, 2001). However, in 40 ET patients, only the baseline platelet value was reported (Cinar et al, 2021). These alterations in blood parameters-erythrocytosis and thrombocytosis-are correlated with changes in cerebral blood perfusion as measured by mean flow velocities and the detection of MES.…”

“…TCD detected MES in four studies (Del Sette et al, 1995;Segura et al, 2000;Blaser et al, 2001;Cinar et al, 2021) with three reporting bilateral findings (Segura et al, 2000;Blaser et al, 2001;Cinar et al, 2021) and one study documenting unilateral MES (Del Sette et al, 1995). A total of 14 patients (22%) had MES monitoring, showing an average of 132 HITS on the right and 38 HITS on the left in 30 minutes to 1-hour monitoring of MCA.…”

“…Of the five studies reviewed, three were case reports wherein there were two cases of PV and one case of ET (Del Sette et al, 1995;Segura et al, 2000;Blaser et al, 2001), one was an observational study with a sample size of 20 newly diagnosed PV patients (Fiermonte et al, 1993), and another was a prospective case-control study with a sample size of 40 ET patients, age and sex-matched with 40 healthy controls (Cinar et al, 2021). In total, 63 patients were included in this review; 27 were male, and 36 were female.…”

“…Meanwhile, essential thrombocytosis was diagnosed according to the WHO 2008 diagnostic criteria for ET (Cinar et al, 2021). Platelet function tests, such as template bleeding time, platelet glass retention, quantitative clot retraction, and induced platelet aggregation by ADP, were also performed (Blaser et al, 2001).…”

“…One study did not specify the MFV (Blaser et al, 2001). However, 40 ET patients reported significantly elevated MFV despite treatment compared to the control group (Cinar et al, 2021). The authors explained that high platelet values may form aggregates and cause obstruction by preventing blood cell passage which was subsequently measured as high MFV.…”