Determination of cinnamaldehyde, coumarin and cinnamyl alcohol in cinnamon and cassia by high-performance liquid chromatography

Archer, Alan W.

doi:10.1016/0021-9673(88)90035-0

Cited by 39 publications

(31 citation statements)

References 9 publications

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“…In our cinnamon extract, we did not detect ions corresponding to cinnamaldehyde by UPLC-MS analysis. Compared to C. cassia (1.99%) or C. zeylanicum bark (2.56%), cinnamaldehyde concentration was lower in C. burmannii bark (0.054%) by hot methanol extraction (Archer, 1988). Additionally, the aqueous extraction method used in this study would not efficiently extract volatile oils such as cinnamaldehyde.…”

Section: Discussionmentioning

confidence: 93%

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

et al. 2012

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Cinnamon has a long history of medicinal use and continues to be valued for its therapeutic potential for improving metabolic disorders such as type 2 diabetes. In this study, a phytochemically-enhanced functional food ingredient that captures water soluble polyphenols from aqueous cinnamon extract (CE) onto a protein rich matrix was developed. CE and cinnamon polyphenol-enriched defatted soy flour (CDSF) were effective in acutely lowering fasting blood glucose levels in diet-induced obese hyperglycemic mice at 300 and 600 mg/kg, respectively. To determine mechanisms of action, rat hepatoma cells were treated with CE and eluates of CDSF at a range of 1–25 µg/ml. CE and eluates of CDSF demonstrated dose-dependent inhibition of hepatic glucose production with significant levels of inhibition at 25 µg/ml. Furthermore, CE decreased the gene expression of two major regulators of hepatic gluconeogenesis, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. The hypoglycemic and insulin-like effects of CE and CDSF may help to ameliorate type 2 diabetes conditions.

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Section: Discussionmentioning

confidence: 93%

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

et al. 2012

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“…So the benzoic acid which has a similar chemical structure as that of cinnamaldehyde was introduced as the internal standard in this study. Regarding the choice of solvent for optimal extraction, methanol was used for developing CC fingerprint in previous studies [15,17]. Extraction efficiency of methanol/ water at ratios of 100:0, 95:5, 90:10, 80:20, 50:50, and 0:100 were examined by ultrasonic extraction.…”

Section: Cluster Analysismentioning

confidence: 99%

Quality assessment of Cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis

Yang

Chen

Zhang

et al. 2007

J of Separation Science

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HPLC fingerprint analysis, principle component analysis (PCA), and cluster analysis were introduced for quality assessment of Cortex cinnamomi (CC). The fingerprint of CC was developed and validated by analyzing 30 samples of CC from different species and geographic locations. Seventeen chromatographic peaks were selected as characteristic peaks and their relative peak areas (RPA) were calculated for quantitative expression of the HPLC fingerprints. The correlation coefficients of similarity in chromatograms were higher than 0.95 for the same species while much lower than 0.6 for different species. Besides, two principal components (PCs) have been extracted by PCA. PC1 separated Cinnamomum cassia from other species, capturing 56.75% of variance while PC2 contributed for their further separation, capturing 19.08% variance. The scores of the samples showed that the samples could be clustered reasonably into different groups corresponding to different species and different regions. The scores and loading plots together revealed different chemical properties of each group clearly. The cluster analysis confirmed the results of PCA analysis. Therefore, HPLC fingerprint in combination with chemometric techniques provide a very flexible and reliable method for quality assessment of traditional Chinese medicines.

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“…Cinnamomum zeylanicum , also known as Ceylon cinnamon or ‘true cinnamon’ is indigenous to Sri Lanka [18]. One significant difference between the two varieties is their coumarin content [24]. Coumarins are naturally occurring plant compounds with strong anticoagulant, carcinogenic and hepato‐toxic properties [25].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of ‘true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta‐analysis

Ranasinghe¹,

Jayawardana²,

et al. 2012

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Aims Diabetes is a leading cause of morbidity and mortality worldwide. Studies have frequently looked at dietary components beneficial in treatment and prevention. We aim to systematically evaluate the literature on the safety and efficacy of Cinnamomum zeylanicum on diabetes.Methods A comprehensive search of the literature was conducted in the following databases; PubMed, Web of Science, Biological Abstracts, SciVerse Scopus, SciVerse ScienceDierect, CINAHL and The Cochrane Library. A meta-analysis of studies examining the effect of C. zeylanicum extracts on clinical and biochemical parameters was conducted. Data were analysed using RevMan v5.1.2.Results The literature search identified 16 studies on C. zeylanicum (five in-vitro, six in-vivo and five in-vivo ⁄ in-vitro). However, there were no human studies. In-vitro C. zeylanicum demonstrated a potential for reducing post-prandial intestinal glucose absorption by inhibiting pancreatic a-amylase and a-glucosidase, stimulating cellular glucose uptake by membrane translocation of glucose transporter-4, stimulating glucose metabolism and glycogen synthesis, inhibiting gluconeogenesis and stimulating insulin release and potentiating insulin receptor activity. The beneficial effects of C. zeylanicum in animals include attenuation of diabetes associated weight loss, reduction of fasting blood glucose, LDL and HbA 1c , increasing HDL cholesterol and increasing circulating insulin levels. Cinnamomum zeylanicum also significantly improved metabolic derangements associated with insulin resistance. It also showed beneficial effects against diabetic neuropathy and nephropathy, with no significant toxic effects on liver and kidney and a significantly high therapeutic window.Conclusion Cinnamomum zeylanicum demonstrates numerous beneficial effects both in vitro and in vivo as a potential therapeutic agent for diabetes. However, further randomized clinical trials are required to establish therapeutic safety and efficacy.

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Determination of cinnamaldehyde, coumarin and cinnamyl alcohol in cinnamon and cassia by high-performance liquid chromatography

Cited by 39 publications

References 9 publications

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix

Quality assessment of Cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis

Efficacy and safety of ‘true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta‐analysis

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