Determination of Commercial Animal and Vegetable Milks’ Lipid Profile and Its Correlation with Cell Viability and Antioxidant Activity on Human Intestinal Caco-2 Cells

Aresta, Antonella; Santis, Stefania De; Carocci, Alessia; Barbarossa, Alexia; Ragusa, Andrea; Vietro, Nicoletta De; Clodoveo, Maria Lisa; Zambonin, Carlo

doi:10.3390/molecules26185645

Cited by 7 publications

(3 citation statements)

References 64 publications

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“…However, about the effect of LPS on the viability of macrophage, there are some different views. Some studies suggested that LPS had no significant effect on the viability of macrophages ( 50 – 54 ), some literatures mentioned that LPS could reduce the viability of macrophages ( 55 , 56 ), while other studies showed that LPS could increase the viability of macrophages ( 57 , 58 ). Consistent with the latter, our results showed that LPS could increase the viability of macrophages.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking

Ding

Wei

et al. 2022

Front. Cardiovasc. Med.

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Hawthorn leaves, which is a traditional Chinese medicine (TCM), has been used for treating coronary heart disease (CHD) for a long time in China. But the limited understanding of the main active components and molecular mechanisms of this traditional medicine has restricted its application and further research. The active compounds of hawthorn leaves were obtained from TCMSP database and SymMap database. The targets of it were predicted based on TCMSP, PubChem, Swiss Target Prediction, and SymMap database. The putative targets of CHD were gathered from multi-sources databases including the Online Mendelian Inheritance in Man (OMIM) database, the DrugBank database, the GeneCards database and the DisGeNet database. Network topology analysis, GO and KEGG pathway enrichment analyses were performed to select the key targets and pathways. Molecular docking was performed to demonstrate the binding capacity of the key compounds to the predicted targets. Furthermore, RAW264.7 cells stimulated by lipopolysaccharides (LPS) were treated with three effective compounds of hawthorn leaves to assess reliability of prediction. Quercetin, isorhamnetin and kaempferol were main active compounds in hawthorn leaves. Forty four candidate therapeutic targets were identified to be involved in protection of hawthorn leaves against CHD. Additionally, the effective compounds of it had good binding affinities to PTGS2, EGFR, and MMP2. Enrichment analyses suggested that immune inflammation related biological processes and pathways were possibly the potential mechanism. Besides, we found that three predicted effective compounds of hawthorn leaves decreased protein expression of PTGS2, MMP2, MMP9, IL6, IL1B, TNFα and inhibited activation of macrophage. In summary, the present study demonstrates that quercetin, kaempferol and isorhamnetin are proved to be the main effective compounds of hawthorn leaves in treatment of CHD, possibly by suppressing expression of PTGS2, MMP2, MMP9, inflammatory cytokines and macrophages viability. This study provides a new understanding of the active components and mechanisms of hawthorn leaves treating CHD from the perspective of network pharmacology.

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Section: Discussionmentioning

confidence: 99%

Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking

Ding

Wei

et al. 2022

Front. Cardiovasc. Med.

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“…The fatty acid (FA) composition of PBBs is generally comprised of long-chain FAs [32]. This leads to the contribution of polyunsaturated fatty acids (PUFAs), which are beneficial for cholesterol management, i.e., low-density lipoprotein.…”

Section: Types and (Anti-)nutritional Profilesmentioning

confidence: 99%

Insights and Perspectives on Plant-Based Beverages

Popova,

Mihaylova,

Lante

2023

Plants

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The emerging demand for everyday food substitutes is increasing on a daily basis. More and more individuals struggle with allergies and intolerances, which makes it mandatory to provide alternatives for simple products like dairy milk. Plant-based beverages (PBBs) are currently trending due to the multiple diets that promote their consumption with or without a justification. PBBs can derive from various types of plants, not exclusively nuts. Some of the most well-known sources are almonds, soy, rice, and hazelnuts, among others. In view of the need for sustainable approaches to resource utilization and food production, novel sources for PBBs are being sought, and those include fruit kernels. The plant kingdom offers a palette of resources with proven bioactivity, i.e., containing flavonoids, phenolic acids, vitamins, carotenoids, and phenolics, among others. Many of these beneficial substances are water soluble, which means they could be transferred to the plant beverage compositions. The current review aims at comparing the vast number of potential formulations based on their specific nutritional profiles and potential deficiencies, as well as their expected health-promoting properties, based on the raw material(s) used for production. Special attention will be given to the antinutrients, usually abundant in plant-based sources.

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“…1 The rational nutrient composition of plant-based milk, such as plant protein, fatty acid profile, polyphenols, and fiber, impart great physicochemical and biological properties to the final products. 2 However, many plant-based milk substitutes, especially those products based on nuts enriched with lipid content, face inescapable challenges related to their physical stability. Given the consumer demands for natural and clean label foods, finding approaches for safe and shelf-stable plant-based milk is indispensable.…”

Section: Introductionmentioning

confidence: 99%