2023
DOI: 10.3390/ijms24119160
|View full text |Cite
|
Sign up to set email alerts
|

Determination of Common microRNA Biomarker Candidates in Stage IV Melanoma Patients and a Human Melanoma Cell Line: A Potential Anti-Melanoma Agent Screening Model

Elena Antonova,
Anastasia Hambikova,
Denis Shcherbakov
et al.

Abstract: MicroRNAs (miRNAs) are small, non-coding RNAs that play an important role in regulating gene expression. Dysregulation of miRNA expression is commonly observed in cancer, and it can contribute to malignant cell growth. Melanoma is the most fatal type of skin malignant neoplasia. Some microRNAs can be prospective biomarkers for melanoma in stage IV (advanced) at higher risk of relapses and require validation for diagnostic purposes. This work aimed to (1) determine the most significant microRNA biomarker candid… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2023
2023
2025
2025

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 69 publications
0
1
0
Order By: Relevance
“…Depending on the type of cancer under investigation, abnormal miRNA expression profiles have been found to correlate with various disease stages, overall prognosis, tumor recurrence, and potential responsiveness to therapeutic interventions [111,117]. In patients with melanoma, different miRNAs can be either up-or down-regulated, and have been correlated with progression-free survival and overall survival [118][119][120]. Interestingly, serum levels of various microRNAs can discriminate between melanoma stages with increased accuracy compared to S100B or LDH [121].…”
Section: Micrornamentioning
confidence: 99%
“…Depending on the type of cancer under investigation, abnormal miRNA expression profiles have been found to correlate with various disease stages, overall prognosis, tumor recurrence, and potential responsiveness to therapeutic interventions [111,117]. In patients with melanoma, different miRNAs can be either up-or down-regulated, and have been correlated with progression-free survival and overall survival [118][119][120]. Interestingly, serum levels of various microRNAs can discriminate between melanoma stages with increased accuracy compared to S100B or LDH [121].…”
Section: Micrornamentioning
confidence: 99%