Determination of Creatinine and Related Guanidinium Compounds

Pilsum, Van; John, Fay M.

doi:10.1002/9780470110232.ch6

Cited by 24 publications

References 64 publications

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Calcium Channel Blockade in Experimental Aminoglycoside Nephrotoxicity

Watson

Gimenez

Klassen

et al. 1987

The Journal of Clinical Pharma

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Calcium channel blocker therapy has proved protective in certain models of ischemic-induced acute renal failure. This effect may be related to the prevention of calcium influx into injured cells or by the vasodilatory effects of verapamil that may result in an improvement in renal blood flow. In the current study, the effect of verapamil treatment on the development of renal insufficiency and renal tissue calcium accumulation following aminoglycoside administration was investigated. The degree of functional damage and cortical tissue calcium accumulation after six or nine days of gentamicin administration (120 mg/kg body weight/day) was not significantly different in rats whose drinking water contained verapamil (10 mg/100 cc) than corresponding values in control animals. The tissue calcium accumulation correlated with the degree of reduction of creatinine clearance and probably reflects the extent of lethal tubular cell injury.

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Calcium Channel Blockade in Experimental Aminoglycoside Nephrotoxicity

Watson

Gimenez

Klassen

et al. 1987

The Journal of Clinical Pharma

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Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3‐methylhistidine excretion in the urine

et al. 1984

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Myofibrillar protein catabolic rate was calculated in 50 young patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and was found to be about seven times that of a control series, expressed as the percentage of myofibrillar protein catabolized per day. This wastage of myofibrillar protein is a consequence of Duchenne muscular dystrophy and inhibition of protein degradation appears to be one possible approach in the treatment of this disease.

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Biochemistry of Selected Amino Acids

Strecker

1970

Metabolic Reactions in the Nervous System

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Determination of Creatinine and Related Guanidinium Compounds

Cited by 24 publications

References 64 publications

Calcium Channel Blockade in Experimental Aminoglycoside Nephrotoxicity

Calcium Channel Blockade in Experimental Aminoglycoside Nephrotoxicity

Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3‐methylhistidine excretion in the urine

Biochemistry of Selected Amino Acids

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