Determination of cyanuric acid residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography–tandem mass spectrometry

Karbiwnyk, Christine M.; Andersen, Wendy C.; Turnipseed, Sherri B; Storey, Joseph M; Madson, Mark R.; Miller, Keith E.; Gieseker, Charles M.; Miller, Ron; Rummel, Nathan; Reimschuessel, Renate

doi:10.1016/j.aca.2008.08.037

Cited by 79 publications

(60 citation statements)

References 16 publications

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“…Currently, various methods-including thin-layer chromatography [6], gas chromatography (GC) [7,8], high-performance liquid chromatography [9][10][11][12], enzyme-linked immunosorbent assay technology [13], matrix-assisted laser desorption/ ionization mass spectrometry (MALDI-MS) [14], and surface desorption atmospheric pressure chemical ionization mass spectrometry [15]-have been used to detect melamine in food. However, these methods usually suffer from drawbacks, such as the need for a complicated sample preparation process, clean-up steps, and a time-consuming determination process, so they cannot fulfill the requirement for fast in situ detection.…”

Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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A surface-enhanced Raman scattering (SERS) strategy based on 4-mercaptopyridine (MPY)-modified gold nanoparticles (AuNPs) was developed for the rapid and sensitive detection of melamine in milk powder. The SERS measurement of melamine strongly relied on the "hotspot" effect, in which AuNPs immediately aggregated upon the addition of melamine, leading to significantly enhanced Raman intensity of the reporter molecule MPY and a color change for the solution from red to blue-gray. The limit of detection based on a signal to noise of 3 (S/N=3) was found to be as low as 0.1 ppb of melamine, with an excellent linearity of 0.5-100 ppb, demonstrating a higher sensitivity and a wider quantitation range than direct SERS sensing methods based on enhanced substrate. An impressive specificity for melamine detection over various common metal ions and excipients in dairy products, even at concentrations of 100-fold higher than melamine, was achieved. Good recoveries of 88.5% and 111.7% were obtained from milk samples spiked to 20 and 100 ppb levels, respectively. The proposed method is potentially applicable for the rapid in situ determination of melamine in complex matrices.

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Section: Introductionmentioning

confidence: 99%

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

et al. 2011

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“…Various techniques including HPLC-UV [10][11][12] or hydrophilic interaction liquid chromatography (HILIC)-UV [13], HPLC-MS [14][15][16][17][18][19][20][21][22][23][24], GC-MS [24][25][26], desorption ionization MS [27], CE [28][29][30], electrochemical method [31], etc., have been used to detect melamine or cyanuric acid. For the simultaneous determination of melamine and cyanuric acid, HPLC-MS [32] and MALDI-MS [33] were employed.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

Xia

Zhou

et al. 2010

J of Separation Science

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Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatographyelectrospray mass spectrometryA hydrophilic interaction liquid chromatography coupled to ESI-MS (HILIC/ESI-MS) method for the simultaneous determination of melamine and related compounds, i.e. ammeline, ammelide and cyanuric acid in foods was developed and validated. The separation was accomplished on a Venusil HILIC column with a mobile phase of acetonitrile 1 10 mM ammonium formate buffer solution at pH 3.5 (88:12, v/v) under isocratic elution mode. For the detection of the targets, the ESI probe worked in the positive and negative switching mode. For each compound, three ions were selected as qualitative ions to obtain high specificity, and the most abundant ion of each compound was selected for quantification to obtain high sensitivity. The target compounds were quantified using SIM with 15N3-melamine and 13C3-cyanuric acid being used as an internal standards in the positive and negative modes, respectively. Compared with RP separation mode, HILIC has merits such as high separation and anti-interference efficiency. The method validation including linearity, LOD, LOQ, precision and recovery proved that the method has merits such high sensitivity, specificity and simplicity versus the other methods reported in the literature.

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“…Most of the recent studies dealing with the determination of CA have used different modes of the more selective MS detection allowing an unambiguous identification and more accurate quantification of target analyte. Liquid chromatography coupled with mass spectrometry (LC-MS) 21 or tandem mass spectrometry using the triple quadrupole mass analysers (LC-MS/MS) has been employed as a sensitive technique for determination of CA residues in pet food 22 and infant formula samples, 23 fish and shrimp tissues, 24 kidney tissue, 25 and human urine. 21,26 CA was detected using the electrospray ionisation [21][22][23][24]26 or atmospheric pressure chemical ionisation 25 in negative ion mode.…”

Section: Cyanuric Acidmentioning

confidence: 99%

Applicability of Liquid Chromatography with Time-of-Flight Mass Spectrometric Detection for Determination of Cyanuric Acid in Soil

Stipičević¹,

Mendaš²,

Vuletić³

et al. 2013

Croat. Chem. Acta

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Abstract. Cyanuric acid (2,4,6-trihydroxy-1,3,5-triazine, CA) is a highly polar and hydrophilic degradation product of symmetric triazine herbicides, fairly stable under environmental conditions. We investigated the applicability of reversed-phase liquid chromatography coupled to time-of-flight mass spectrometry (LC-ToF-MS) for qualitative and quantitative determination of CA in soils of different origin and pedological characteristics. CA was ultrasonically extracted from soils either with a mixture of acetone and n-hexane (volume ratio = 2 : 1) or with methanol and analysed on a LiChrospher 100 CN column with ψ(acetonitrile,water) = 50 : 50 as the mobile phase for isocratic elution. The efficiency and selectivity of LC-ToF-MS determination, using the electrospray ionisation in negative mode and selective monitoring of deprotonated CA molecule (m/z 128), was evaluated with respect to injection volume, extracting solvent, and possible soil matrix interferences. The advantage of LC-ToF-MS over conventional HPLC with UVdiode array detection was the high ion detection selectivity minimising the interferences of coeluting species and the unambiguous identification of CA in soil extracts by accurate mass measurements of deprotonated molecule. (doi: 10.5562/cca2109)

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Determination of cyanuric acid residues in catfish, trout, tilapia, salmon and shrimp by liquid chromatography–tandem mass spectrometry

Cited by 79 publications

References 16 publications

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Rapid detection of melamine with 4-mercaptopyridine-modified gold nanoparticles by surface-enhanced Raman scattering

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

Applicability of Liquid Chromatography with Time-of-Flight Mass Spectrometric Detection for Determination of Cyanuric Acid in Soil

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