Determination of cytotoxic, genotoxic, and oxidative damage from deltamethrin on primary hepatocyte culture of Lake Van fish,Alburnus tarichi

Kiraççakali, Ayşe N.; Oğuz, Ahmet

doi:10.1080/02757540.2020.1781098

Cited by 11 publications

(5 citation statements)

References 38 publications

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“…ALP and LDH play a significant role in phosphate hydrolysis, [35]. Similar alteration in ALT, AST, ALP and LDH was also reported by [36] Alburnus tarichi. A similar trend in L. rohita was reported by [28] Das and Mukherjee (2003) upon cypermethrin exposure.…”

Section: Discussionsupporting

confidence: 74%

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (Ctenopharyngodon idella)

Khan¹,

Ahmad²,

Ghayyur³

et al. 2022

Pol. J. Environ. Stud.

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The current study was designed to evaluate the comparative effects of three selected chemicals such as emamectin (insecticide), acetochlor (herbicide) and topsin-M (fungicide) on haematology, biochemical profile and histopathology of grass carp (Ctenopharyngdon idella). A total of forty C. Idella was collected from fish farm Hattian Kamra and transported to the Chemistry lab of Government Post Graduate College Haripur in plastic bags containing dissolve oxygen. After acclimatization for a week they were randomly segregated in four groups (E0, E1, E2 and E3) and treated with 5ppb emamectin, acetochlor and topsin-M respectively. After 96hrs of chemical treatment, blood and tissue samples were collected from both control and treated groups for investigation of biochemical and histopathological alterations. Obtained results exhibited significant alteration in haematological parameters i.e. total white blood cells count, MCV, MCH and number of platelets significantly (p<0.05) increased while Red blood cells count, hemoglobin, PCV and MCHC significantly (p<0.05) decreased in the experimental groups E1, E2 and E3 as compared to control group. Significant (p<0.05) changes were observed in biochemical parameters i.e. increase in serum glucose, bilirubin, albumins, blood urea, uric acid, cholesterol, serum calcium, phosphorous, sodium, potassium, serum lipase, CKP, LDH and CK MB, while significant decrease in creatinine, triglycerides, HDL-cholesterol, serum iron, serum amylase, SGPT, alkalinity and Phosphate was observed. The observed Histopathological changes in gills include epithelial

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Section: Discussionsupporting

confidence: 74%

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (Ctenopharyngodon idella)

Khan¹,

Ahmad²,

Ghayyur³

et al. 2022

Pol. J. Environ. Stud.

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“…Previous studies in aquatic organisms have reported that DM had estrogenic, 6 genotoxic, 13,14 neurotoxic, 15−17 and immunotoxic effects 4 similar to those reported following exposure to other pyrethroids. 12,18 Cardiotoxicity has also been observed in rat, 19 quails, 20 crucian carp, 21 and zebrafish 13,20 L caused cardiac morphological and functional defects in zebrafish. Hepatotoxicity was also previously observed presenting fibrosis and steatosis.…”

Section: Introductionmentioning

confidence: 60%

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio)

Wang,

Li,

Liu

et al. 2024

Environ. Sci. Technol.

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Deltamethrin (DM) is a widely used insecticide that has demonstrated developmental toxicity in the early life stages of fish. To better characterize the underlying mechanisms, embryos from Tg(cmlc2:RFP), Tg(apo14:GFP), and Tg(mpx:GFP) transgenic strains of zebrafish were exposed to nominal DM concentrations of 0.1, 1, 10, 25, and 50 μg/L until 120 h postfertilization (hpf). Heart size increased 56.7%, and liver size was reduced by 17.1% in zebrafish exposed to 22.7 and 24.2 μg/L DM, respectively. RNA sequencing and bioinformatic analyses predicted that key biological processes affected by DM exposure were related to inflammatory responses. Expression of IL-1 protein was increased by 69.0% in the 24.4 μg/L DM treatment, and aggregation of neutrophils in cardiac and hepatic histologic sections was also observed. Coexposure to resatorvid, an antiinflammatory agent, mitigated inflammatory responses and cardiac toxicity induced by DM and also restored liver biomass. Our data indicated a complex proinflammatory mechanism underlying DM-induced cardiotoxicity and hepatotoxicity which may be important for key events of adverse outcomes and associated risks of DM to early life stages of fish.

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“…The study of the ALT and AST activity has recently been used, not only in clinical practice to diagnose diseases associated with impaired liver function, but also to research the toxicity of various drugs to 2D and 3D hepatocyte cultures [ 65 , 66 , 67 , 68 ]. Based on this, in our investigation, the analysis of the AST and ALT activity in the culture medium was used to determine the degree of copper-containing compound toxicity in relation to the primary culture of hepatocytes.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole

et al. 2021

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A new original copper nanocomposite based on poly-N-vinylimidazole was synthesized and characterized by a complex of modern physicochemical and biological methods. The low cytotoxicity of the copper nanocomposite in relation to the cultured hepatocyte cells was found. The possibility to involve the copper from the nanocomposite in the functioning of the copper-dependent enzyme systems was evaluated during the incubation of the hepatocyte culture with this nanocomposite introduced to the nutrient medium. The synthesized new water-soluble copper-containing nanocomposite is promising for biotechnological and biomedical research as a new non-toxic hydrophilic preparation that is allowed to regulate the work of key enzymes involved in energy metabolism and antioxidant protection as well as potentially serving as an additional source of copper.

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Determination of cytotoxic, genotoxic, and oxidative damage from deltamethrin on primary hepatocyte culture of Lake Van fish,Alburnus tarichi

Cited by 11 publications

References 38 publications

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Comparative Effects of Selected Agrochemicals on Biochemical Profile and Histopathology of Grass-Carp (<i>Ctenopharyngodon idella</i>)

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio)

Evaluation of the Safety and Toxicity of the Original Copper Nanocomposite Based on Poly-N-vinylimidazole

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