Determination of d-Mannose in Plasma by HPLC

Taguchi, Tadao; Miwa, Izumi; Mizutani, T.; Nakajima, Hitoshi; Fukumura, Yukihito; Kobayashi, Isao; Yabuuchi, Masahiko; Miwa, Ichitomo

doi:10.1373/49.1.181

Cited by 34 publications

(27 citation statements)

References 10 publications

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“…In the past, determination of plasma mannose required special equipment and was time consuming, but in recent years, it can be achieved quickly and conveniently by HPLC (24) or an automated method using aldohexose dehydrogenase (22). With these techniques, the concentration of plasma mannose has been shown to decrease significantly 30 -60 min after oral administration of glucose to healthy individuals (22,24).In mammalian cells, the donor GDP-mannose used for glycoprotein and glycolipid synthesis is derived through the pathway mannose 6-phosphate3mannose 1-phosphate3 GDPmannose. Mannose 6-phosphate is assumed to be formed by the following two pathways (5): 1) isomerization of intracellular fructose 6-phosphate by mannose-6-phosphate isomerase and 2) phosphorylation of mannose imported into the cell via a mannose-specific transporter.…”

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confidence: 99%

“…The concentration of free mannose in plasma ranges from 20 to 80 M in healthy adults (7,20,(22)(23)(24) but is elevated in patients with invasive candidiasis associated with immune deficiency (13,21) and is decreased in patients with carbohydrate-deficient glycoprotein syndrome (2,9,16). In diabetic patients, the plasma concentrations of mannose are high, and plasma concentrations of mannose and glucose are positively correlated (19,22,24).…”

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confidence: 99%

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Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration

Taguchi¹,

Yamashita²,

Mizutani³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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D-mannose is an essential monosaccharide constituent of glycoproteins and glycolipids. However, it is unknown how plasma mannose is supplied. The aim of this study was to explore the source of plasma mannose. Oral administration of glucose resulted in a significant decrease of plasma mannose concentration after 20 min in fasted normal rats. However, in fasted type 2 diabetes model rats, plasma mannose concentrations that were higher compared with normal rats did not change after the administration of glucose. When insulin was administered intravenously to fed rats, it took longer for plasma mannose concentrations to decrease significantly in diabetic rats than in normal rats (20 and 5 min, respectively). Intravenous administration of epinephrine to fed normal rats increased the plasma mannose concentration, but this effect was negated by fasting or by administration of a glycogen phosphorylase inhibitor. Epinephrine increased mannose output from the perfused liver of fed rats, but this effect was negated in the presence of a glucose-6-phosphatase inhibitor. Epinephrine also increased the hepatic levels of hexose 6-phosphates, including mannose 6-phosphate. When either lactate alone or lactate plus alanine were administered as gluconeogenic substrates to fasted rats, the concentration of plasma mannose did not increase. When lactate was used to perfuse the liver of fasted rats, a decrease, rather than an increase, in mannose output was observed. These findings indicate that hepatic glycogen is a source of plasma mannose.

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confidence: 99%

mentioning

confidence: 99%

Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration

Taguchi¹,

Yamashita²,

Mizutani³

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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“…As mentioned previously, mannose can be synthesized from glucose (Wood and Cahill 1963) either in the form of ingested glucose or as a breakdown product from hepatic glycogen (Taguchi et al 2003;Taguchi et al 2005). As such, the second hypothesis therefore was that an increase in circulating mannose levels may result from ingested glucose.…”

Section: Discussionmentioning

confidence: 92%

“…Mannose can be synthesized from glucose via a cellular enzymatic pathway involving the phosphorylation of hexose intermediates (Sone et al 2003). The glucose can either be in the form of ingested glucose or as a breakdown product from hepatic glycogen (Taguchi et al 2003;Taguchi et al 2005). As such, this study had two working hypotheses in mind.…”

Section: Discussionmentioning

confidence: 99%

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Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

et al. 2008

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Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.

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Manifesting Subtle Differences of Neutral Hydrophilic Guest Isomers in a Molecular Container by Phase Transfer

Lee

Jang

et al. 2016

Angewandte Chemie

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Achieving strong host-guest interactions between synthetic hosts and hydrophilic guests in solution is challenging because solvation effects overwhelm other effects. To resolve this issue, we transferred complexes of cucurbit [7]uril (CB[7]) and monosaccharides to the gas phase and report here their intrinsic host-guest chemistry in the absence of solvation effects. It was observed that effective host-guest interactions in the gas phase mediated by ammonium cations allow the differentiation of the monosaccharide isomers in complex with CB[7] upon vibrational excitation. The potential of the unique observation was extended to a quantitative supramolecular analytical method for the monosaccharide guests. The combination of host-guest chemistry and phase transfer presented in this study is an effective approach to overcome current limitations in supramolecular chemistry.

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Determination of d-Mannose in Plasma by HPLC

Cited by 34 publications

References 10 publications

Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration

Hepatic glycogen breakdown is implicated in the maintenance of plasma mannose concentration

Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

Manifesting Subtle Differences of Neutral Hydrophilic Guest Isomers in a Molecular Container by Phase Transfer

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