Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS

Abdel‐Hamid, Mohammed E.; Novotný, Ladislav; Hamza, Hoda

doi:10.1016/s0731-7085(00)00444-1

Cited by 121 publications

(52 citation statements)

References 19 publications

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“…The fabricated sensor was employed for the determination of flufenamic acid in biological samples. Flufenamic acid (FFA), N-(α,α,α-trifluoro-m-tolyl) an anthranilic acid derivative (Scheme 1), is an effective analgesic, an antiinflammatory and antipyretic agent used for the relief of pain and inflammation associated with musculoskeletal and joint disorders, peri-articular and soft tissue disorders, antirheumatic therapy.1,2 Monitoring of therapeutic drug habitually necessitates its detection in biological fluids.Many analytical methods based on different principles, such as spectrophotometry, 3-6 spectrofluorimetry, 5,11 fluorescence spectrometry, 7-10 flow injection analysis, 11,12 chromatography [13][14][15] have been developed for the analysis of flufenamic acid along with its derivatives. Capillary electrophoresis [16][17][18] is an alternative methodology for the separation and detection of FFA.…”

mentioning

confidence: 99%

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Shetti

Nayak

Malode

et al. 2016

J. Electrochem. Soc.

104

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In the current research, ruthenium stood a conspicuous dopant for TiO 2 nanoparticles, to enhance its catalytic activity. The characterization of synthesized nanoparticles was accomplished by utilizing XRD, SEM, EDX and TEM analysis. The sensing surface morphology was studied by AFM analysis. Further, we established the electrochemical behavior and detection of flufenamic acid (FFA) by utilizing ruthenium doped TiO 2 nanoparticles modified carbon paste electrode (Ru-TiO 2 /CPE) at pH 6.0 by employing different voltammetric techniques. Modification enhances the electro-oxidation of flufenamic acid with increased current intensity. The influence of parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the peak current of the drug were studied. The effect of FFA concentration variation was studied using square wave voltammetric (SWV) technique and got lowest detection limit compared to reported techniques. The fabricated sensor was employed for the determination of flufenamic acid in biological samples. Flufenamic acid (FFA), N-(α,α,α-trifluoro-m-tolyl) an anthranilic acid derivative (Scheme 1), is an effective analgesic, an antiinflammatory and antipyretic agent used for the relief of pain and inflammation associated with musculoskeletal and joint disorders, peri-articular and soft tissue disorders, antirheumatic therapy.1,2 Monitoring of therapeutic drug habitually necessitates its detection in biological fluids.Many analytical methods based on different principles, such as spectrophotometry, 3-6 spectrofluorimetry, 5,11 fluorescence spectrometry, 7-10 flow injection analysis, 11,12 chromatography [13][14][15] have been developed for the analysis of flufenamic acid along with its derivatives. Capillary electrophoresis [16][17][18] is an alternative methodology for the separation and detection of FFA. However, these methods are well-demonstrated and broadly accepted, but they require moderately costly equipment, laborious sample pretreatment, specialized expertise, high cost and are time-consuming which make them unsuitable for routine analysis. Few voltammetric studies 5,19 were also carried out by utilizing cyclic voltammetry and adsorptive voltammetry. Though, these sensors suffer from the less sensitive, poor long-term stability, lack of surface renewability, etc.As of late, research developed, aiming at the construction and the characterization of the electrodes composed of carbonaceous materials because of their rich surface chemistry, lower background current, wider potential window, uncomplicated surface renewal and low detection limit properties. [20][21][22][23][24] The fabrication of the working electrode with nanoparticles enhances peak current, sensitivity, reproducibility. 25,26 In current science and technology, one of the crucial uniqueness is to survey and to discover the new efficient materials as electrode surface modifiers.In general, new types of sensor devices are the outcome of the synthesis and preparation of innovative modifiers. In this regard, as e...

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confidence: 99%

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Shetti

Nayak

Malode

et al. 2016

J. Electrochem. Soc.

104

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“…The total analytical time for a single analytical run was approximately 11 min. A single run time was longer than that reported in the previously published LC-MS method with APCI [28]. However, in this present method, all analytes were separated by LC and the matrix effect was reduced by the column switching procedure.…”

Section: Switching Timementioning

confidence: 67%

“…And due to their polar nature, it is difficult to separate most underivatized NSAIDs by GC. The determination of four NSAIDs by LC-MS with atmospheric pressure chemical ionization (APCI) was also reported [28]. However, LC-MS with APCI was applied only to dosage forms.…”

Section: Introductionmentioning

confidence: 98%

Direct determination of non-steroidal anti-inflammatory drugs by column-switching LC–MS

Suenami¹,

Lim

Takeuchi

et al. 2006

J. Sep. Sci.

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A method for determination of 16 non-steroidal anti-inflammatory drugs (NSAIDs) in human plasma samples without time-consuming sample pre-treatments was developed. The system consisted of two pumps for mobile phase delivery, a six-port switching valve, a pre-column (Oasis HLB Cartridge Column), and a reversed phase analytical column (COSMOSIL 3C18-MS-II). The analytes were trapped on the precolumn and subsequently separated on the analytical column. The present method allowed on-line sample clean-up and enrichment, leading to improved sensitivity without any tedious sample preparation. The recoveries of NSAIDs from human plasma by column-switching were greater than 72.6%. The total analysis time for a single analytical run was approximately 11 min. The detection limits of NSAIDs were 0.0025 to 0.2 microg/mL using the selected ion monitoring mode.

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“…Numerous methods are available for the determination of indomethacin, including gas chromatography (GC) [4,5], GC-mass spectrometry [6], high performance liquid chromatographic (HPLC) methods [7][8][9][10][11][12][13][14][15][16][17][18], HPLC-mass spectrometry [19,20] and capillary electrophoresis (CE) [21][22][23][24][25]. Indomethacin has an active carboxyl group in the structure.…”

Section: Introductionmentioning

confidence: 99%

Determination of indomethacin in plasma by micellar electrokinetic chromatography with UV detection for premature infants with patent ducts arteriosus

Lin

Chen

et al. 2006

Journal of Chromatography B

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Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS

Cited by 121 publications

References 19 publications

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Direct determination of non-steroidal anti-inflammatory drugs by column-switching LC–MS

Determination of indomethacin in plasma by micellar electrokinetic chromatography with UV detection for premature infants with patent ducts arteriosus

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Determination of diclofenac sodium, flufenamic acid, indomethacin and ketoprofen by LC-APCI-MS

Cited by 121 publications

References 19 publications

Electrochemical Sensor Based upon Ruthenium Doped TiO2Nanoparticles for the Determination of Flufenamic Acid

Electrochemical Sensor Based upon Ruthenium Doped TiO2Nanoparticles for the Determination of Flufenamic Acid

Direct determination of non-steroidal anti-inflammatory drugs by column-switching LC–MS

Determination of indomethacin in plasma by micellar electrokinetic chromatography with UV detection for premature infants with patent ducts arteriosus

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Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid

Electrochemical Sensor Based upon Ruthenium Doped TiO₂Nanoparticles for the Determination of Flufenamic Acid