Determination of dipyridamole in pharmaceutical preparations using square wave voltammetry

Toledo, Renata Alves de; Castilho, Marilza; Mazo, Luiz Henrique

doi:10.1016/j.jpba.2004.09.011

Cited by 23 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…) is a well-known vasodilator drug that has been widely used for treatment of coronary heart diseases, 1 and a classic platelet inhibitor being a key medicine in clinical therapy of thrombosis and cerebrovascular disease. This drug possesses pleiotropic anti-inflammatory, antiproliferative and anti-oxidant actions.…”

mentioning

confidence: 99%

Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples

Mirzajani¹,

Arefiyan²

2019

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

A dipyridamole (DIP) based surface molecularly imprinted polymer (MIP) was synthesized and applied as a sensing agent in a sensing layer of a new modified potentiometric carbon paste electrode (CPE). The potentiometric modified CPEs (GO@SiO 2-NH 2-MIP/MWCNTs/CPE, where GO is graphene oxide and MWCNTs is multi-walled carbon nanotubes) showed an improved performance in term of Nernstian slope, selectivity and response time compared to the unmodified CPE. The response time of the sensor in the range of 2.5 × 10-8-1.1 × 10-2 M DIP was 20 s. The obtained DIP sensor showed low limit of detection (1 × 10-8 M), and satisfactory long-term stability (higher than 4 months). The practical application of the sensor was demonstrated by the determination of DIP concentration in urine samples and pharmaceutical preparations, with good precision and acceptable recoveries (96.0-103.0%). The prepared sensor showed high selectivity for DIP over a number of common species (aspirin, caffeine, ascorbic acid, glucose, urea, bipyridine,

show abstract

mentioning

confidence: 99%

Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples

Mirzajani¹,

Arefiyan²

2019

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…DIP's electrochemical (cathodic [1] and anodic [2,3,27,28]) behavior was investigated in aqueous [1,27], micellar [28], and nonaqueous media [2,3] at different electrodes, e.g., Pd [3], Pt [2,3,27], mercury-coated platinum microelectrode [1], glassy carbon, and graphite [28]. On the other hand, there are few literature reports related to voltammetric methods developed for DIP quantification in pharmaceutical [14,[29][30][31] and biological samples [14,15,31,32].…”

Section: Introductionmentioning

confidence: 99%

Novel voltammetric investigation of dipyridamole at a disposable pencil graphiteelectrode

David¹,

Iordache²,

Popa³

et al. 2019

Turk J Chem

View full text Add to dashboard Cite

The present paper describes the voltammetric analysis of dipyridamole (DIP) at a cheap, disposable pencil graphite electrode (PGE). The working conditions were optimized with regard to the electrode material and the supporting electrolyte. Cyclic voltammetric investigations emphasized that DIP is irreversibly oxidized at the PGE. The electrode process is pH-dependent and controlled by both diffusion and adsorption. For DIP quantitative determination a differential pulse voltammetric (DPV) method in phosphate buffer solution pH 7.00 was developed. DIP's oxidation peak current varied linearly with the analyte concentration, presenting two linear ranges, namely 5.00 × 10 −7-2.50 × 10 −5 M and 2.50 × 10 −5-2.50 × 10 −4 M, with detection and quantification limits of 1.21 × 10 −7 M and 4.03 × 10 −7 M DIP, respectively. The newly developed DPV method using the inexpensive, disposable PGE was successfully applied for the simple and rapid determination of DIP from pharmaceutical formulations.

show abstract

“…In addition, electrochemical methods offer ease of operation, simple instrumentation, and are less sensitive to matrix effects than other analytical techniques [12,13]. It has been found that the use of modified electrode enhances the sensitivity for electrochemical determination of biomolecules and drugs [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Carbon nanotube-based electrochemical sensor for the determination of halobetasol propionate, a topical corticosteroid

Goyal

Agrawal

2011

J Appl Electrochem

View full text Add to dashboard Cite

Electrocatalytic reduction of halobetasol propionate (HBP) at single-walled carbon nanotube (SWCNT) modified edge plane pyrolytic graphite electrode (EPPGE) was performed by square wave voltammetry and cyclic voltammerty in phosphate buffer of pH 7.2. The surface morphology of SWCNT/EPPGE was characterized by field emission scanning electron microscopy. The enhanced peak current (i p ) and lower reduction peak potential (E p ) at modified electrode as compared to bare electrode were obvious evidences for the electrocatalytic ability of SWCNT toward the reduction of HBP. The cathodic peak current varied linearly with concentration of HBP in the range 0.02 to 1 mM with sensitivity of 2.432 lA mM -1 and detection limit (3r/slope) of 10 lM. The product of electrochemical reduction of HBP was characterized using FT-IR and 1 H-NMR spectroscopic techniques. A tentative mechanism for the formation of product was suggested and it was found that reduction of [C=O occurred at position three. The proposed methodology was successfully applied to the detection of HBP in pharmaceutical preparations.

show abstract

Determination of dipyridamole in pharmaceutical preparations using square wave voltammetry

Cited by 23 publications

References 23 publications

Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples

Construction and Evaluation of a Graphene Oxide Functionalized Aminopropyltriethoxy Silane Surface Molecularly Imprinted Polymer Potentiometric Sensor for Dipyridamole Detection in Urine and Pharmaceutical Samples

Novel voltammetric investigation of dipyridamole at a disposable pencil graphiteelectrode

Carbon nanotube-based electrochemical sensor for the determination of halobetasol propionate, a topical corticosteroid

Contact Info

Product

Resources

About