2014
DOI: 10.14233/ajchem.2014.16631
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Determination of Dopamine, Glycine, Tryptohan, Valine, Leucine and Isoleucine Using 4-Dimethylaminobenzaldehyde by HPLC in Pharmaceutical Samples

Abstract: A simple isocratic HPLC procedure has been developed for simultaneous separation and quantitation of dopamine, glycine, tryptophan, valine, leucine and isolucine by pre-column derivatization with 4-dimethylaminobenzaldehyde and UV detection at 240 nm. The derivatives formed were examined spectrophotomatrically for the effects of pH, derivatizing reagent concentration and heating time in aqueousmethanolic solution. The analytes and excess of the derivatizing reagent separated completely from the column Kromasil… Show more

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“…The currently reported assays include ultraviolet (UV)‐visible spectrophotometry [13], high‐performance liquid chromatography (HPLC) [14], electrochemical methods [15], capillary electrophoresis [16], chemiluminescence [17], and so forth. Although these techniques are accurate, they are often time‐consuming, lack sensitivity, or require complex equipment.…”
Section: Introductionmentioning
confidence: 99%
“…The currently reported assays include ultraviolet (UV)‐visible spectrophotometry [13], high‐performance liquid chromatography (HPLC) [14], electrochemical methods [15], capillary electrophoresis [16], chemiluminescence [17], and so forth. Although these techniques are accurate, they are often time‐consuming, lack sensitivity, or require complex equipment.…”
Section: Introductionmentioning
confidence: 99%