Determination of Doxorubicin and Doxorubicinol in Plasma of Cancer Patients by High-Performance Liquid Chromatography

Quantitative liquid chromatographic analysis of anthracyclines in biological fluids

“…From the 35 publications included in this overview, 12 quantify only one main compound [26,[42][43][44][45][46][47][48][49][50][51][52]. Others determine a main compound and its reduced metabolite [27,[53][54][55][56][57][58][59], sometimes together with additional 8 metabolites [24,[60][61][62][63][64][65][66][67]. One method could be applied to each of the four pairs (main compound and respective reduced metabolite) individually [68].…”

Selective determination of doxorubicin and doxorubicinol in rat plasma by HPLC with photosensitization reaction followed by chemiluminescence detection

“…To date, a number of publications have been reported of the determination of DXR and its metabolite DXR-ol including capillary electrophoresis (CE) with UV detection [4] or laser-induced fluorescence (LIF) detection [5][6][7], radioimmunoassay [8], high performance liquid chromatography (HPLC) with ultraviolet (UV) detection [9][10], fluorescence detection [11][12][13][14][15][16][17][18][19][20][21], chemiluminescence detection [22], electrochemical detection [23] and mass spectrometric detection [25][26][27][28][29]. However, many of these methods lack the enough sensitivity and selectivity which enable the determination of DXR and DXR-ol at small plasma concentration while the high cost and the need for technical experience limits the use of the others.…”

Clinical and Pharmacokinetic Characteristics of Intracavitary Administration of Pegylated Liposomal Encapsulated Doxorubicin in Dogs with Splenic Hemangiosarcoma

“…23 In addition, peritoneal fluid samples were collected via ultrasoundguided abdominocentesis at 5 minutes and 1 hour after treatment. These samples were obtained via separate catheters.…”