Determination of drug levels in human serum by circular dichroism

Features of electronic circular dichroism and tips for its use in determining absolute configuration

“…The method was successfully applied to the direct determination of these drugs in oral suspension, injections, and capsules, 22 as well as in human urine, 23 and human serum. 24 Some general features of the exciton chirality method are:…”

Electronic circular dichroism for the detection of microalbuminuria

“…[1][2][3][4][5] It has also been used to resolve the structure of several vital biomolecules. [9][10][11][12][13][14][15][16][17] A number of them have successfully used chiroptical spectroscopy of blood plasma, serum, or urine for [This article is part of the Special Issue: Proceedings 16th International Conference on Chiroptical Spectroscopy, Rennes France 2017. However, the vast majority of chiroptical studies have been devoted to single molecules or simple systems, which are not burdened by the complexity of real biofluids.…”

“…[6][7][8] Because the structure-function relationship of a molecule is strongly dependent on its natural environment, the analysis of biomolecules directly in biofluids is essential for a deeper insight into many biological processes. pharmacokinetic studies, 9,10,12,13 cholesterol quantification, 18 and even the determination of disease-specific spectral signatures. Some researchers, however, have attempted to overcome issues such as low concentrations of clinically significant molecules, high level of fluorescence, and undesirable interferences disturbing the signals of interest by using chiroptical spectroscopy in biofluid analysis.…”

“…Some researchers, however, have attempted to overcome issues such as low concentrations of clinically significant molecules, high level of fluorescence, and undesirable interferences disturbing the signals of interest by using chiroptical spectroscopy in biofluid analysis. [9][10][11][12][13][14][15][16][17] A number of them have successfully used chiroptical spectroscopy of blood plasma, serum, or urine for [This article is part of the Special Issue: Proceedings 16th International Conference on Chiroptical Spectroscopy, Rennes France 2017. See the first articles for this special issue previously published in Volume 30:4.…”

“…More special articles will be found in this issue as well as in those to come.] pharmacokinetic studies, 9,10,12,13 cholesterol quantification, 18 and even the determination of disease-specific spectral signatures. 19,20 However, the potential of chiroptical spectroscopy for the direct monitoring of urinary albumin levels in diabetic patients remains untapped.…”