Determination of ethylenediamine tetraacetic acid in injection forms by ion-pair chromatography

Flow Injection Chemiluminescence Determination of EDTA in Canned Food

“…It can be seen that the proposed method is far more sensitive than spectrophotometry (Parkash et al 1998;Hamano et al 1993), rapid than colorimetry (Hamano et al 1985), GC-MS (Nishikawa and Okumura 1995), and HPLC (Jong et al 1991;Kord et al 1995;Zhao et al 2001 andPistos andPoulou 2002). Compared with other CL methods, the proposed method is simple, rapid with high sensitivity and has wide linear range, which makes the proposed system an efficient and better protocol than the procedure described by Tomas et al Ruiz et al (2008).…”

“…Gas chromatographic methods (Sorvari et al 1996;Nishikawa and Okumura 1995;Retho and Diep 1989) always include a time-consuming derivatization step, in which EDTA is converted into methyl, ethyl, propyl, or butyl esters to obtain volatility. Similarly, HPLC methods are mainly based on a precolumn derivatization step in which complexation of EDTA with Cu 2þ or Fe 3þ is conducted (Jong et al 1991;Kord et al 1995;Zhao et al 2001;Pistos and Poulou 2002;Gucht 1994), while postcolumn derivatization for the formation of fluorescent ternary complexes has also been reported (Ye and Lucy 1996).…”

Development and validation of a method for the determination of EDTA in non-alcoholic drinks by HPLC

“…The commonly used methodologies for EDTA quantification in different types of samples (pharmaceutical forms, drinking waters, sauces, mayonnaises and others) are based upon the complex formation of EDTA with copper (Kord et al, 1995;Pistos and Parissi-Poulou, 2002) or Iron salts (Shimadzu, 2005;Fidler Meredith, 2003;Yamaguchi et al, 1983). Some authors use DAD detectors (Fidler Meredith, 2003: Yamaguchi et al, 1983 and other use UV detectors (Kord et al, 1995;Pistos and ParissiPoulou, 2002;Shimadzu, 2005).…”