Determination of etidronic acid in vegetable-washing water by a simple and validated quantitative 31P nuclear magnetic resonance method

Belmonte-Sánchez, José Raúl; Aguilera-Sáez, Luis Manuel; Romero‐González, Roberto; Vidal, José Luis Martı́nez; Arrebola, Francisco

doi:10.1016/j.microc.2019.104083

Cited by 6 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The use of 1 H NMR, as a technique for BPs quantification, was intensely evaluated by our group, and previous studies showed that the error margin is very narrow [27,28,37]. The precision of this method is consistent with other quantification studies in food samples using 31 P NMR spectroscopy [40].…”

Section: Repeatability and Reproducibility Of The Release Experimentssupporting

confidence: 77%

Surface-Modified Silica Hydrogels for the Programmable Release of Bisphosphonate Anti-Osteoporosis Drugs: The Case of Etidronate

et al. 2023

View full text Add to dashboard Cite

Bisphosphonate drugs constitute the primary treatment for bone diseases such as Paget’s disease and osteoporosis. Despite their effectiveness, they also exhibit severe drawbacks, such as rapid excretion and limited oral bioavailability. High doses are usually administered to counterbalance these drawbacks. Subsequently, side effects are triggered, such as osteonecrosis of the lower jaw and esophageal cancer. Controlled drug release systems may be viable candidates to overcome those issues. Herein, we present novel functionalized silica-based hydrogels loaded with the osteoporosis drug etidronate (1,1-hydroxyethylidene-diphosphonate) used to control the release profile of the drug. Various methodologies were evaluated to control the initial release rate and the final released concentration of the drug. These included the gel density, by systematically increasing the initial concentration of silicate used to prepare the hydrogels, the presence of metal cations (Ca2+ and Cu2+), and the internal surface functionalization of the gel with silane-based grafting agents (with anionic, cationic, and neutral groups). This study also contributes to our continuous effort to develop new a priori programmable drug-loaded gels for the controlled release of osteoporosis drugs.

show abstract

Section: Repeatability and Reproducibility Of The Release Experimentssupporting

confidence: 77%

Surface-Modified Silica Hydrogels for the Programmable Release of Bisphosphonate Anti-Osteoporosis Drugs: The Case of Etidronate

et al. 2023

View full text Add to dashboard Cite

show abstract

Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological materials: An updated review

Manousi

Tzanavaras

Zacharis

2022

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Benchtop NMR spectroscopy for quantitative determination of milk fat and qualitative determination of lactose: From calibration curve to deep learning

Belmonte-Sánchez,

Romero-González,

Martínez Orosa

et al. 2024

LWT

View full text Add to dashboard Cite

Determination of etidronic acid in vegetable-washing water by a simple and validated quantitative 31P nuclear magnetic resonance method

Cited by 6 publications

References 35 publications

Surface-Modified Silica Hydrogels for the Programmable Release of Bisphosphonate Anti-Osteoporosis Drugs: The Case of Etidronate

Surface-Modified Silica Hydrogels for the Programmable Release of Bisphosphonate Anti-Osteoporosis Drugs: The Case of Etidronate

Determination of bisphosphonate active pharmaceutical ingredients in pharmaceuticals and biological materials: An updated review

Benchtop NMR spectroscopy for quantitative determination of milk fat and qualitative determination of lactose: From calibration curve to deep learning

Contact Info

Product

Resources

About