2022
DOI: 10.21203/rs.3.rs-2152713/v1
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Determination of feeding rate ratio in coupled fed-batch fermentation with pH feedback considering limited number of switches

Abstract: This paper focuses on binary optimal control of fed-batch fermentation of glycerol by Klebsiella pneumoniae with pH feedback considering limited number of switches. To maximize the concentration of 1,3-propanediol at terminal time, we propose a binary optimal control problem subjected to time-coupled combinatorial constraint with the ratio of feeding rate of glycerol to that of NaOH as control variables. Based on time-scaling transformation and discretization, the binary optimal control problem is first transf… Show more

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