Determination of Felodipine in Tablets Using Accelerated Solvent Extraction

Determination of organic impurities in pharmaceutical preparations

“…The use of Soxhlet extraction [34], SFE [35][36][37][38][39], ultrasonic solvent extraction, and ASE [40] makes it possible to decrease the amount of the solvent, to increase the extraction coefficient, and to decrease the time of extraction and the cost of sample preparation. However, currently these methods are rarely used for the extraction of impurities from pharmaceutical preparations.…”

Leveraging elevated temperature and particle size reduction to extract API from various tablet formulations

“…Increased temperature accelerates the extraction kinetics, and elevated pressure keeps the solvent below its boiling point enabling safe and rapid extractions. ASE has been used for assay and content uniformity determination for pharmaceutical dosage forms, including extended release tablets [2,3], chewable tablets [4,5], and transdermal patches [3,6]. As an example, Hoang et al [5] used ASE to extract an LTD4 antagonist from a chewable tablet formulation for content uniformity analysis.…”

PLE in the analysis of plant compounds

“…PLE was originally developed for sample preparation in environmental analysis [6,11]. More recently, PLE application has been extended onto other sample types: biological, pharmaceutical and foodstuffs [12,13].…”

“…Although this is a relatively simple method, it suffers from such disadvantages as long extraction time, relatively high solvent consumption and often unsatisfactory reproducibility [5]. Recently, an innovative sample preparation technique, pressurised liquid extraction (PLE), has been more and more often applied [6][7][8][9][10]. The growing popularity of PLE results mainly from the possibility of eliminating the drawbacks mentioned above.…”