Determination of flavonoids in<i>Flos Chrysanthemi</i>and<i>Flos Chrysanthemi Indici</i>by capillary electrophoresis

Wu, Tingni; Yu, Chang-Zhu; Rong, Li

doi:10.1080/10739149.2016.1258572

Cited by 12 publications

(2 citation statements)

References 19 publications

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“…The GC-MS technique analyzes the volatile oil constituents from Sonchus arversis L. has reported acacetin as the main constituents account for 0.94% of total volatile oil (QIAO and LIU, 2008). Several recent studies used the CE method for determining flavonoids in various plant species and detected the occurrence of acacetin in all samples tested (Chu et al, 2010;Peng et al, 2005;Wu et al, 2017;YU et al, 2011). A highly specified but sensitive electrospray ionization liquid chromatography-tandem mass spectrometry method (EILC-TMS) is recently designed to explore flavonoids (Hossain et al, 2010;Li et al, 2019;Tahri et al, 2016;Zhong et al, 2019;Zhou et al, 2010).…”

Section: Analytical Techniques Of Acacetinmentioning

confidence: 99%

A comprehensive review of pharmacological and Analytical Aspects of Acacetin

Yao¹,

Zhu²,

Liu³

et al. 2021

NRFHH

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Among the large group of natural polyphenolic flavonoids, acacetin is widely distributed throughout the plant kingdom and remained the part of the food and traditional medication systems across the globe. Acacetin is found naturally in more than 200 plant species belongs to 60 different plant families, but mostly in Asteraceae and Lamiaceae families in the genus of Artemisia, Cirsium, Dendranthema, Saussurea, Dracocephalum, and Origanum. In Traditional Chinese Medicine (TCM) system, plant extracts having acacetin with various biological activities are given to cure different ailments including microbial or viral infections, cardiovascular issues, blood glucose fluctuations or diabetes, neurological and immunological disorders, hyperlipidemia, chronic inflammations, cancers or tumor control, hepatic issues, and lot more to count. Acacetin mainly exerts its remarkable effects both at transcriptional as well as translational levels. Acacetin suppressed the phosphorylation of p38 mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB, and reduces lipid peroxidation through reactive oxygen species (ROS) scavenging capability. For many proteins and enzymes, acacetin directly binds with them to regulate their activities, and hence acts as a potent inhibitor of that particular function such as inhibition of sortase enzyme, translational protein enzymes, aldose reductase enzyme, inhibition of cell signaling channels and molecules, and much more. It is concluded that acacetin has the potential to use as a potent inhibitor of multiple proteins, enzymes, signaling molecules and ion channels. These properties make acacetin an appealing candidate to be designed and screened for use as a multipurpose inhibitor for diseases.

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Section: Analytical Techniques Of Acacetinmentioning

confidence: 99%

A comprehensive review of pharmacological and Analytical Aspects of Acacetin

Yao¹,

Zhu²,

Liu³

et al. 2021

NRFHH

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“…Hence, the efficient and accurate determination of the content of baicalein in medicine is of significant value in the medical field. Conventional detection methods, such as capillary electrophoresis [11], high-performance liquid chromatography [12], and chromatography-mass spectrometry [13], are powerful and reliable but are expensive and time-consuming. With the advantages of high sensitivity, good selectivity, and fast response [14], the electrochemistry detection method is a popular and affordable way to detect substances.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of baicalein based on a three-dimensional micromixer

Liang

Yang

et al. 2020

J. Micromech. Microeng.

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Baicalein, a kind of flavonoid, has many medical benefits, and therefore, its accurate and efficient determination is necessary in the field of medical ingredient detection. To achieve the rapid and precise detection of baicalein, a three-dimensional (3D) expansion–contraction wave micromixer was designed and used along with an electrochemical detection method to assemble a micromixing electrochemical detection system. First, the performances of the wave micromixers were investigated using the COMSOL Multiphysics 5.3 a software with three optimisation objectives, namely, the mixing uniformity, pressure drop, and mixing performance index, to comprehensively evaluate the properties of the micromixers. Second, a 3D expansion–contraction wave micromixer with optimal mixing properties was fabricated using the 3D printing technology. Third, a micromixing electrochemical detection system was built to study the redox behaviours of baicalein through the electrochemical cyclic voltammetry method. The effects of buffer varieties, buffer pH values, scanning speeds, and inlet flow rates on the redox curves of baicalein were studied to determine the appropriate experimental conditions. The results demonstrated that the currents of the oxidation peak increased linearly with the baicalein concentrations within the range of 3.55 × 10−6–5.92 × 10−5 mol l−1 and the detection limit of 1.861 × 10−8 mol l−1 (S/N = 3). The relative standard deviation among the results obtained through repeated experiments was 2.86%; this proves a high detection reproducibility of the new method. Compared with spectrophotometry, the error determined using the novel method in a real sample detection was 0.31%, thus achieving an efficient and precise detection of baicalein. The micromixing electrochemical detection method can remarkably improve the mixing efficiency, shorten the detection time, and decrease the detection limit, and therefore could be popularised for the exact content detection of other flavonoids.

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Sensitive Determination of Diosmetin Using Orange‐Red Fluorescent Copper Nanoclusters

Yang,

Kuang,

Yuan

et al. 2024

ChemistrySelect

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Diosmetin (Dio) has attracted much attention because of its good pharmacological effects, thus it is necessary to determine its content in scientific research and production. In the study, stable orange‐red copper nanoclusters with 4‐hydroxy‐2‐mercapto‐6‐propylpyrimidine (PTU) as reducing agent and ligand (PTU‐CuNCs) was prepared by a simple approach with superior quantum yield (18.03 %), and the PTU‐CuNCs with red fluorescence could improve the anti‐interference ability of detection. Meanwhile, the synthesis conditions of PTU‐CuNCs were optimized and analyzed in detail. Through a series of experiments, it was found that inner filter effect (IFE) and dynamic quenching might become the main reasons for the fluorescence quenching of PTU‐CuNCs by Dio. Based on the mechanism, a fluorescence probe for the determination of Dio was established. In the range of 0.33–31.67 μmol L−1, the fluorescence quenching efficiency of PTU‐CuNCs was linearly related to the contents of Dio, and corresponding limit of determination (LOD) was estimated to be 101.3 nmol L−1, and limit of quantitation (LOQ) was calculated to be 337.4 nmol L−1. Furthermore, the method could be used effectively for the assay of Dio in practical samples.

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Determination of flavonoids inFlos ChrysanthemiandFlos Chrysanthemi Indiciby capillary electrophoresis

Cited by 12 publications

References 19 publications

A comprehensive review of pharmacological and Analytical Aspects of Acacetin

A comprehensive review of pharmacological and Analytical Aspects of Acacetin

Electrochemical detection of baicalein based on a three-dimensional micromixer

Sensitive Determination of Diosmetin Using Orange‐Red Fluorescent Copper Nanoclusters

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