Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection

Xu, Xueqin; Yu, Lishuang; Chen, Guonan

doi:10.1016/j.jpba.2006.01.013

Cited by 159 publications

(83 citation statements)

References 14 publications

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“…Purslane shows higher amounts than many other plants of certain biological components, including oleic acid, linoleic acid and γ-linolenic acid, and has been reported to suppress cancer or be effective in decreasing the occurrence rate of heart diseases (9,10). Also, purslane contains great amounts of nutrients such as tocopherol and ascorbic acid (11).…”

Section: Introductionmentioning

confidence: 99%

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

Lee¹,

Shin²,

Kang³

et al. 2011

JFN

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This study was initiated to investigate the effects of lyophilized purslane (Portulaca oleracea) powder (5% and 10%) on lipid levels in rats fed a hypercholesterolemia-inducing diet (1% cholesterol). During the four week study, there were no significant differences in either weight change or the food efficiency ratio between the group fed the hypercholesterol diet alone (HC) and the groups fed the purslane powder (HCPO-I and HCPO-II, 5% and 10% purslane, respectively). In serum, the levels of total lipid, total cholesterol and LDL-C decreased significantly for the group fed the 10% purslane powder (HCPO-II) in comparison with the group fed the 5% purslane powder (HCPO-I). The atherogenic index (AI) was reduced by about 51% for the group fed the 10% purslane powder (1.47) in comparison with the HC group (3.03). The activities of GOT, GPT, ALP and LDH decreased significantly for the groups fed the purslane powder in comparison with the HC group. Regarding liver tissue, the levels of total lipid, total cholesterol and triglyceride decreased significantly for the purslane powder-fed rats compared to the HC group. The fecal lipid profiles increased significantly as the amount of purslane powder was increased. Compared to the HC group, the fecal total cholesterol and triglyceride levels were higher in the group fed the 10% purslane powder by about 2.8 times and 2.3 times, respectively. For the serum and liver tissue, the content of lipid peroxide decreased significantly in the groups fed purslane powder compared to the HC group. The data from this experiment show an increase in the lipid levels discharged in feces, suggesting that the supplementation of purslane powder to a hypercholesterolemia-inducing diet reduces lipid levels.

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Section: Introductionmentioning

confidence: 99%

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

Lee¹,

Shin²,

Kang³

et al. 2011

JFN

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“…In additional, several reports showed that flavonoids, coumarins, terpenoids, alkaloids, and fatty acids were isolated from P. oleracea (Awad, 1994 andSakai et al, 1996;Liu et al, 2000). Xu et al (2006) reported that five flavonoids (kaempferol, apigenin, myricetin, quercetin and luteolin) were isolated from P. oleracea by capillary electrophoresis with electrochemical detection. Flavonoids, as a class of naturally occurring compounds found in most vascular plants, have been demonstrated by a number of groups to be centrally active, possessing efficacies for a number of receptor systems in the CNS.…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Lee¹,

Yoon²,

Ryu³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe purpose of this study was to characterize the putative anxiolytic-like effects of the 70% ethanol extract of Portulaca oleracea (EPO) using an elevated plus maze (EPM) in mice. The EPO was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM, respectively. Control mice were treated with an equal volume of 10% tween 80, and positive control mice with diazepam (1 mg/kg). Single treatments of the EPO significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus controls (P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolyticlike effects of the EPO were blocked by flumazenil (10 mg/kg, i.p), a GABA receptor antagonist. These results indicate that P. oleracea is an effective anxiolytic agent, and suggest that the anxiolytic-like effects of P. oleracea is mediated via the GABAergic nervous system.

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“…As P. oleracea L. is also a widespread and abundant plant in the world, much attention has been paid to its pharmacological study, such as its anti-inflammatory and anti-pruritic (Lim et al, 2011), hypocholesterolemic (Movahedian, Ghannadi, Vashimia, 2007) and hypoglycemic (Gong et al, 2009) effects. Some reports have focused on in vitro and in vivo analyses of the components in P. oleracea L. extract (POE) i.e., flavonoids, by capillary electrophoresis with electrochemical detection (Xu, Yu, Chen, 2006), and four compounds of POE have been detected in rat plasma by HPLC after intravenous administration of P. oleracea L. (Cheng et al, 2012). However, there is little known regarding the tissue distribution and excretion of POE.…”

Section: Introductionmentioning

confidence: 99%

Tissue distribution and excretion of the five components of Portulaca oleracea L. extract in rat assessed by UHPLC

Zhang

Leng

et al. 2015

Braz. J. Pharm. Sci.

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The aim of the present study was to investigate the tissue distribution and excretion of five components of Portulaca oleracea L. extract (POE) in rat following oral administration. A rapid, sensitive and specific ultra-high performance liquid chromatography (UHPLC) method with puerarin as the internal standard was used for the quantitative analysis of five components of POE, including caffeic acid (CA), p-coumaric acid (p-CA), ferulic acid (FA), quercitrin (QUER) and hesperidin (HP) in rat tissues including the liver, intestine, stomach, muscle, heart, lung, brain, kidney and spleen, urine and feces. The results show that only p-CA and FA were found in nearly all tissues with low cumulative ratios, and CA was higher in the intestine and stomach with a slightly higher cumulative ratio in the urine and feces after 24 h. HP and QUER were found at low levels in the tissues with low cumulative ratios. O objetivo do presente estudo foi investigar a distribuição tecidual e excreção de cinco componentes de extrato Portulaca oleracea L. (POE) em ratos após administração oral. Um método analítico rápido, sensível e específico para quantificação de cinco componentes de POE (ácido cafeico (CA), ácido p-cumárico (p-CA), ácido ferúlico (FA), quercitrina (QUER) e hesperidina (HP)) por cromatografia líquida de ultra eficiência (UHPLC), empregando puerarina como padrão interno de referência. Os compostos foram quantificados em diferentes tecidos dos animais, sendo eles fígado, intestino, estômago, músculo, coração, pulmão, cérebro, rim e baço, urina e fezes. Os resultados mostraram que apenas p-CA e FA foram encontradas em todos os tecidos com baixas taxas cumulativas e CA apresentou níveis mais altos no intestino e estômago com a taxa cumulativa um pouco mais elevada na urina e nas fezes após 24 h. HP e QUER apresentaram baixas concentrações nos tecidos com baixas taxas cumulativas.Uniterms: Portulaca oleracea L./farmacocinética. Portulaca oleracea L./extrato/estudo experimental. Portulaca oleracea L./extrato/distribuição tecidual. Portulaca oleracea L./extrato/excreção. Compostos fenólicos. Cromatografia líquida de ultra eficiência/análise quantitativa.

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Determination of flavonoids in Portulaca oleracea L. by capillary electrophoresis with electrochemical detection

Cited by 159 publications

References 14 publications

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

Effects of Portulaca oleracea Powder on the Lipid Levels of Rats Fed a Hypercholesterolemia Inducing Diet

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Tissue distribution and excretion of the five components of Portulaca oleracea L. extract in rat assessed by UHPLC

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