“…The bioavailability and pharmacokinetic profiles of these two galantamine formulations were evaluated with a hairless guinea pig model and a sensitive and high-throughput method is required to complete the study. Previously, the measurement of galantamine was accomplished in relatively simple matrices such as plants and pharmaceutical dosage forms, with various analytical methods utilizing HPLC-UV (Li & Yang, 2014), capillary electrophoresis (Rizzi et al, 1999) and spectrofluorimetry (Patel, Patel, Patel, Dave, & Patel, 2013). For more complex biological matrices, two HPLC-UV methods (Claessens, van Thiel, Westra, & Soeterboek, 1983;Tencheva, Yamboliev, & Zhivkova, 1987) were first reported in the 1980s as well as two HPLC-fluorescence methods (Malakova et al, 2007;Zhang et al, 2007).…”