2013
DOI: 10.4103/0975-7406.120079
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Determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form by spectrofluorimetry

Abstract: Aim:To develop a simple, accurate, sensitive, rapid and precise method for the determination of galantamine hydrobromide in bulk drug and pharmaceutical dosage form.Material and Methods:The method employs wavelength detection and determination of galantamine hydrobromide at excitation wavelength 282 nm and emission wavelength 607 nm in a solution of simple distilled water.Result and Conclusion:The method was found to be linear in the range of 2–14 μg/ml having r2 = 0.9999. The mean accuracy was found to be 98.… Show more

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Cited by 17 publications
(15 citation statements)
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“…The bioavailability and pharmacokinetic profiles of these two galantamine formulations were evaluated with a hairless guinea pig model and a sensitive and high-throughput method is required to complete the study. Previously, the measurement of galantamine was accomplished in relatively simple matrices such as plants and pharmaceutical dosage forms, with various analytical methods utilizing HPLC-UV (Li & Yang, 2014), capillary electrophoresis (Rizzi et al, 1999) and spectrofluorimetry (Patel, Patel, Patel, Dave, & Patel, 2013). For more complex biological matrices, two HPLC-UV methods (Claessens, van Thiel, Westra, & Soeterboek, 1983;Tencheva, Yamboliev, & Zhivkova, 1987) were first reported in the 1980s as well as two HPLC-fluorescence methods (Malakova et al, 2007;Zhang et al, 2007).…”
Section: Cummingsmentioning
confidence: 99%
“…The bioavailability and pharmacokinetic profiles of these two galantamine formulations were evaluated with a hairless guinea pig model and a sensitive and high-throughput method is required to complete the study. Previously, the measurement of galantamine was accomplished in relatively simple matrices such as plants and pharmaceutical dosage forms, with various analytical methods utilizing HPLC-UV (Li & Yang, 2014), capillary electrophoresis (Rizzi et al, 1999) and spectrofluorimetry (Patel, Patel, Patel, Dave, & Patel, 2013). For more complex biological matrices, two HPLC-UV methods (Claessens, van Thiel, Westra, & Soeterboek, 1983;Tencheva, Yamboliev, & Zhivkova, 1987) were first reported in the 1980s as well as two HPLC-fluorescence methods (Malakova et al, 2007;Zhang et al, 2007).…”
Section: Cummingsmentioning
confidence: 99%
“…As of August 2016 perampanel had been studied and development discontinued in migraine, multiple sclerosis, neuropathic pain and Parkinson's disease [5]. Few HPLC methods were reported in the literature for the analysis of perampanel in pharmaceutical formulation [6].…”
Section: Isolation and Spectral Characterization Of Degradation Impurmentioning
confidence: 99%
“…There are many methods for the determination of galantamine, including high‐performance liquid chromatography (HPLC) . The determination of galantamine in dosage form using the UV–photometric method has also been described …”
Section: Introductionmentioning
confidence: 99%