Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Paimard, Giti; Gholivand, Mohammad Bagher; Shamsipur, Mojtaba

doi:10.1016/j.measurement.2015.09.019

Cited by 33 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on the results obtained for G, Acy and Gan and although the molecules in the study did not show Nernstian behaviour, it can be assumed that 2e − /2H + (Scheme 1) are involved in the electrochemical process, consistent with that reported in the literature . In these studies, it has been reported that the oxidation mechanism of G and its pharmaceutical derivatives involves a deprotonation step and probably a breaking of the double bond in the imidazole ring (between the −N(7)=C(8)−) atoms) to give the final product 8‐oxoguanine .…”

Section: Resultssupporting

confidence: 84%

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

et al. 2017

View full text Add to dashboard Cite

An electroanalytical method using square wave voltammetry (SWV) is proposed for the quantification of Guanine (G), 6‐Thioguanine (TG), Acyclovir (Acy) and Ganciclovir (Gan) in different types of pharmacological samples. In addition, for the first time, a study of the electrochemical behavior (using cyclic voltammetry, CV) of guanine and its pharmacological derivatives on fluoride doped oxide (FTO) electrodes was carried out. The study of CV potential scanning demonstrated the charge transfer process was diffusion controlled and the diffusion coefficient was determined for all the studied products. Besides, electrochemical parameters, such as transfer coefficient, heterogeneous charge transfer constant and the number of electrons transferred (e) were determined namely, 4e for TG and 2e for G, Acy and Gan. SWV studies at pH 4 for G and 2 for TG, Acy and Gan showed linear ranges between 4.0×10−6 and 40.0×10−6 mol L−1, with detection limits of 0.91×10−6 for G, and 1.50×10−6 for TG, 1.25×10−6 for Acy and 0.45×10−6 mol L−1 for Gan. The method presents sensitivity and stability appropriate to be employed in quality control and routine quantification of drugs in pharmaceutical formulations.

show abstract

Section: Resultssupporting

confidence: 84%

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

et al. 2017

View full text Add to dashboard Cite

show abstract

“…3) and the slope of 0.635 of the log (I)‐log (υ) plot (Eq. 4) indicate that the electrode process is controlled by diffusion so the slope of 0.635 is close to the expected 0.5 value . However, the oxidation peak potential (E p ) shifted to more positive when scan rate increases.…”

Section: Resultsmentioning

confidence: 99%

“…In an irreversible electrode process, α is about 0.5. Then, the number of electrons transferred, n, is 2.13 (∼2), which is in agreement with the results in the literatures . Therefore, the electrochemical oxidation of GCV involves 2e − and 2H + transfer processes at the modified electrode in the pH range from 1 to 3.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Sensitive Electrochemical Sensor for Voltammetric Determination of Ganciclovir Based on Au‐ZnS Nanocomposite

Yari

Shams

2018

Electroanalysis

View full text Add to dashboard Cite

An electrode modified with ZnS and gold nanoparticles (Au‐ZnS NPs) is introduced for highly sensitive voltammetric determination of ganciclovir (GCV). Surface structure and topography of the modified electrode was studied by SEM, EDX and XRD techniques. Electrochemical oxidation of GCV was investigated by cyclic (CV) and square wave voltammetry (SWV) in Briton‐Robinson buffer solution (pH 1.5). The results showed that electrochemical oxidation of GCV at the Au‐ZnS modified glassy carbon electrode (GCE) is irreversible and exhibited diffusion controlled electrode process over the pH range from 1.0 to 6.0. The oxidation potential peak and pH relationship showed that electrons and protons were transferred simultaneously over the electrochemical oxidation process. Using the proposed sensor, the linear calibration curves were obtained in the ranges of 0.04–1.50 μM and 1.5–70.0 μM with detection limit of 0.01 μM GCV by SWV technique. The modified electrode was successfully applied as a sensitive, reproducible and repeatable sensor for determination of the trace amount of GCV in human serum, urine and cymevene vials. Reasonable results were obtained from comparing the measurements of the real samples by the new sensor to high performance liquid chromatography (HPLC) as a standard method.

show abstract

“…To determine these species, different sensors were developed [14][15][16][17][18][19][20][21][22][23]. Numerous materials, such as humic acids [7,24], metallic complexes [25,26], polymers [27,28], oxides [29,30] or films [31,32] have been used to immobilize different pollutants on the surface of electrodes to use as electrochemical sensors. Indeed, the use of metallic complexes to modify electrodes is very important for applications in the field of electro-analysis.…”

Section: Introductionmentioning

confidence: 99%

A new electrochemical sensor based on carbon paste electrode/Ru(III) complex for determination of nitrite: Electrochemical impedance and cyclic voltammetry measurements

Terbouche

Lameche

Ait‐Ramdane‐Terbouche

et al. 2016

Measurement

View full text Add to dashboard Cite

International audienceThe modified carbon paste electrode with Ru(III) complex was studied as a novel sensor for the determination of nitrite. The behavior of NO2− at the electrode surface was investigated using electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). EIS provided useful information on the charge transfer resistance (R) at the electrode/solution. The EIS measurements showed that R is low at oxidation potentials, and decreases with increasing temperature. The increase of the constant phase element with temperature is due to the accumulation of nitrite on the electrode, thus, facilitating the electron transfer between electrode and NO2−. CV was used to study the effect of pH on the electro-catalytic oxidation of NO2− and to determine the limit of detection (LOD). CV measurements showed a good linear relationship between the oxidation current and the concentration of NO2− over a wide concentration range 0–1.38 × 10−2 mol L−1. Low detection limit of 1.39 × 10−6 mol L−1 toward NO2− was obtained. LOD decreased by 23.2% compared to that determined using cavity microelectrode. © 2016 Elsevier Lt

show abstract

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Cited by 33 publications

References 35 publications

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

A Sensitive Electrochemical Sensor for Voltammetric Determination of Ganciclovir Based on Au‐ZnS Nanocomposite

A new electrochemical sensor based on carbon paste electrode/Ru(III) complex for determination of nitrite: Electrochemical impedance and cyclic voltammetry measurements

Contact Info

Product

Resources

About

Determination of ganciclovir as an antiviral drug and its interaction with DNA at Fe3O4/carboxylated multi-walled carbon nanotubes modified glassy carbon electrode

Cited by 33 publications

References 35 publications

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO2Electrode. Application in Pharmaceutical Preparations

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO2Electrode. Application in Pharmaceutical Preparations

A Sensitive Electrochemical Sensor for Voltammetric Determination of Ganciclovir Based on Au‐ZnS Nanocomposite

A new electrochemical sensor based on carbon paste electrode/Ru(III) complex for determination of nitrite: Electrochemical impedance and cyclic voltammetry measurements

Contact Info

Product

Resources

About

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations

Electrochemical Behaviour Study and Determination of Guanine, 6‐Thioguanine, Acyclovir and Gancyclovir on Fluorine‐doped SnO₂Electrode. Application in Pharmaceutical Preparations