Determination of Gastroduodenal Alkaline Responses Using pH Deflection in the Rat

Takeuchi, Koji; Niida, Hiromichi

doi:10.1097/00004836-199206001-00019

Journal of Clinical Gastroenterology

1992

DOI: 10.1097/00004836-199206001-00019

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Determination of Gastroduodenal Alkaline Responses Using pH Deflection in the Rat

Koji Takeuchi

Hiromichi Niida²

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“…An acid microclimate at the brush border surface has been reported, however, this is maximal in the jejunum [6]. Others have reported that duodenum secretes bicarbonate to neutralize lumenal acid [7]. Much previous work on iron uptake has been performed with duodenal tissue incubated in vitro in media buffered at pH 7.0-7.4 [4,5].…”

mentioning

confidence: 99%

105 Iron and proton uptake by mouse duodenum

Simpson

Jafri

1998

Biochemical Society Transactions

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mentioning

confidence: 99%

105 Iron and proton uptake by mouse duodenum

Simpson

Jafri

1998

Biochemical Society Transactions

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Review article: gastroduodenal bicarbonate secretion

Hogan

Ainsworth

Isenberg

1994

Aliment Pharmacol Ther

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SUMMARYThe gastroduodenal epithelium is covered by an adherent mucus layer into which bicarbonate is secreted by surface epithelial cells. This mucus‐bicarbonate barrier is an important first line of defence against damage by gastric acid and pepsin, and has been demonstrated in all species including human. Similar to gastric acid secretion, regulation of gastric and duodenal bicarbonate secretion can be divided into three phases: cephalic, gastric and duodenal. In humans, sham‐feeding increases bicarbonate secretion in both the stomach and duodenum which is mediated by cholinergic vagal fibres in the stomach, but seems to be noncholinergic in the duodenum. Gastric distention and luminal acidification increases gastric bicarbonate production. Whereas there are no data relating to the gastric phase of human duodenal bicarbonate secretion, in animals, food and acid in the stomach independently stimulate duodenal bicarbonate output. To date, the duodenal phase of human gastric bicarbonate secretion has not been studied, but data from animals reveal that duodenal acidification augments bicarbonate secretion in the stomach. In all species tested, direct acidification of the duodenum is a potent stimulant of local bicarbonate production. In humans, the pH threshold for bicarbonate secretion is pH 3.0. Mediation of gastroduodenal bicarbonate secretion is provided by a variety of agonists and antagonists, tested mainly in animals, but some have been evaluated in humans. Prostaglandins of the E class and VIP are major factors that control bicarbonate secretion. Bicarbonate secretion, and the mucus‐bicarbonate layer in general, is adversely effected by ulcerogenic factors such as aspirin, NSAIDs, bile salts, and cigarette smoking. Furthermore, duodenal ulcer patients have an impairment in bicarbonate production within the duodenal bulb, at rest and in response to stimulation. These findings indicate that the mucus‐bicarbonate barrier is an important first line of defence in the pathogenesis of peptic ulcer disease.

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Determination of Gastroduodenal Alkaline Responses Using pH Deflection in the Rat

Cited by 2 publications

References 0 publications

105 Iron and proton uptake by mouse duodenum

105 Iron and proton uptake by mouse duodenum

Review article: gastroduodenal bicarbonate secretion

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