Determination of Gentamicin Released from Orthopedic Carrier System by a Novel HPLC Method

Laki, Mónika; Ludányi, Krisztina; Hajdú, Melinda; Klebovich, Imre; Antal, István; Zahár, Ákos; Szabó, Miklós

doi:10.1093/chrsci/49.3.177

Cited by 13 publications

(5 citation statements)

References 19 publications

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“…A reversed phase HPLC using Zorbax Rx-C-18 2.1 × 150 mm, 5 µm column with a mobile phase consisted of methanol-water-acetate buffer (0.02 M ammonium acetate solution, adjusted with cc. ammonia to pH = 9 were used for the determination Gentamicin released from orthopedic carrier system [124] .…”

Section: Chromatographic Methodsmentioning

confidence: 99%

Analytical methods for the determination of certain antibiotics used in critically ill patients

Ibrahim

El-Adl

Baraka

et al. 2020

J Pharm Biopharm Res

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Section: Chromatographic Methodsmentioning

confidence: 99%

Analytical methods for the determination of certain antibiotics used in critically ill patients

Ibrahim

El-Adl

Baraka

et al. 2020

J Pharm Biopharm Res

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“…• Laki M, Hajdu M developed a new, fast high-performance liquid chromatographic-UV method for quantitative analysis of gentamicin carrier samples drawn in drug release studies. The mobile phase consisted of methanol-water-acetate buffer (0.02 M ammonium acetate solution, adjusted with ammonia to pH = 9), a reverse phase, Zorbax Rx-C18 column has been used during the analysis [41].…”

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

Analytical Methods for the Determination of Aminoglycosides Antibiotics by Chromatrographic Technique

Sofiqul

Murugan

Kumari

2020

Int J Pharm Pharm Sci

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Aminoglycosides antibiotics are considered to be the antimicrobial agents used frequently in the treatment of human diseases caused by a bacterial infection. Most of the aminoglycosides antibiotics are highly polar in nature and they are lacking the UV absorbing chromophore in the molecules. The present articles accentuate the analytical method associated with the analysis of aminoglycosides molecules. Various chromatographic techniques like liquid chromatography, gas chromatography; mass spectrometry were used for the detection of aminoglycosides antibiotics. However, due to its limitation in the ultraviolet-visible spectrophotometry (UV/Vis) technique, different types of detection techniques like corona-charged aerosol detector (CAD), electrochemical detector (ECD) were used as a most powerful and versatile technique for the demonstration of these molecules in the analytical field. Analytical methods help to ensure the quality of the drug products. This review paper is devoted to providing an overview of the key performance technique used for the application and detection of these aminoglycosides molecules.

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“…It is effective against wide spectrum of gram positive and gram-negative bacteria. 14 This study is designed to incorporate Gentamicin in the transferosomal gel system for transdermal delivery to avoid problems related with its parenteral delivery, and to improve the drug permeation through the skin and finally increase the bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Evaluation of Gentamicin-Loaded Transferosomal Gel

Begum Nooreen,

Azeez Basha,

Mannan

2023

Int J Health Sci Res

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Gentamicin is a broad-spectrum antibiotic that is utilized in treating infections caused by strains of Streptococci, Staphylococci, Pseudomonas, and gram-negative bacteria. Gentamicin, being a BCS class III drug possess poor permeability. The aim of the current research was to formulate and optimize Gentamicin-loaded topical transferosomal gel to enhance its permeability. The components such as, surfactants, edge activators, phospholipids were screened individually with drug. The transferosomal gel formulations were prepared by thin film hydration method. The formulations had particle size ranging from (113.98±2.51 nm) to (309.09±1.10nm), in vitro drug release ranging from (75.98±0.55%) to (97.13±0.24%), Zeta potential(-34.56mV) to (-13.18mV), PDI ranging from (0.205) to (0.542). The Optimization of Transferosomal gel was done on the basis of different concentrations of Carbopol 934 and HPMC k15 and the optimized formulation is characterized for viscosity, spreadability, SEM analysis, pH, drug content and in vitro drug release. The 0.1 % Gentamicin transferosomal gel had Spreadability 0.301±0.25 g.cm/sec, pH value is 6.1. Viscosity of optimized Gentamicin transferosomal gel was found to be 68521cps, and percentage drug release for was 98.59 ± 0.46. Finally, stability studies were carried out for prepared transferosomal gel and it was stable at30℃ ± 2℃ / 65 % ± 5 % RH for 90days. Key words: Gentamicin Transferosomal gel, Transferosomes, Topical, Antibiotic drug, Thin Film Hydration Technique.

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Determination of Gentamicin Released from Orthopedic Carrier System by a Novel HPLC Method

Cited by 13 publications

References 19 publications

Analytical methods for the determination of certain antibiotics used in critically ill patients

Analytical methods for the determination of certain antibiotics used in critically ill patients

Analytical Methods for the Determination of Aminoglycosides Antibiotics by Chromatrographic Technique

Formulation and Evaluation of Gentamicin-Loaded Transferosomal Gel

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