As modern diesel engine design progresses toward higher burst pressure and power density, strict performance indices impose greater demands on the structural strength and reliability of crankshafts. We integrated finite element analysis and strength testing methods to achieve a lightweight crankshaft design. A comparison of the simulated results with the test data revealed that the crankshaft safety factor surpassed the permissible safety factor by 3.5 times, demonstrating significant safety redundancy in the design. We employed topology optimization techniques to create various crankshaft optimization models, yielding near-optimal solutions. Consequently, we identified the crankshaft with the best overall performance following comparative evaluations. We examined the influence of the fillet structure on the safety factor to mitigate stress concentration issues. Through multibody dynamic fatigue analysis, optimizing the crankshaft fillet resulted in a 6~7% increase in the safety factor. The minimum safety factor for the designed crankshaft was 1.6 times higher than the material permissible safety factor, which was 1.15. Utilizing the developed transient dynamics model of the lightweight crankshaft and a backpropagation genetic algorithm, we created a crankshaft fillet design tool to streamline the design process, which holds significant importance for the marine engine sector.