Determination of glycogen, lipids and proteins in hepatic needle biopsy

The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon‐induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave of autophagocytosis in <0.5 h in mouse hepatocytes. Liver glycogen content decreases simultaneously and blood glucose first increased and then decreased below control values. Both liver cAMP concentration and the activity of glycogen phosphorylase remained unchanged. These findings provide evidence tht the induction of autophagocytosis after vinblastine injection is not mediated by cAMP. The increased degradation of glycogen may occur in the lysosomal system by means of increased autophagocytosis.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Determination of glycogen, lipids and proteins in hepatic needle biopsy

Cited by 10 publications

References 14 publications

A simple colorimetric method for determination of serum triglycerides with lipoprotein lipase and glycerol dehydrogenase

A simple colorimetric method for determination of serum triglycerides with lipoprotein lipase and glycerol dehydrogenase

Prevention of 4-pentenoic acid-induced liver injury in rats by 16,16-dimethyl PGE2

Vinblastine‐induced autophagocytosis: effects on liver glycogen

Contact Info

Product

Resources

About