1989
DOI: 10.1002/mrm.1910090207
|View full text |Cite
|
Sign up to set email alerts
|

Determination of halothane distribution in the rat head using 19F NMR technique

Abstract: The distribution of halothane in the rat head was examined with 19F NMR rotating-frame zuegmatography and 2DFT 19F NMR imaging. The rotating frame experiments were conducted at varying times following anesthesia to assess the time dependence of the halothane distribution. The results of these experiments demonstrate that halothane and halothane metabolite are unequally partitioned through the rat tissues examined. 19F spin-echo imaging experiments were conducted immediately following anesthesia. The results of… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
6
0

Year Published

1991
1991
2009
2009

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 31 publications
(6 citation statements)
references
References 18 publications
0
6
0
Order By: Relevance
“…Wyrwicz and co-workers [329][330][331][332][333][334][335][336] addressed the issue of residence times of anesthetics in the brain and observed signals for the anesthetics for prolonged durations after cessation of anesthesia. Both halothane [330] and isoflurane [331] showed bi-compartmental elimination from the rabbit brain with half-lives (t 1/2 of 25 and 320 mins for halothane and 26 and 174 mins for isoflurane).…”
Section: Other Drugs: Retention Of Anestheticsmentioning
confidence: 98%
“…Wyrwicz and co-workers [329][330][331][332][333][334][335][336] addressed the issue of residence times of anesthetics in the brain and observed signals for the anesthetics for prolonged durations after cessation of anesthesia. Both halothane [330] and isoflurane [331] showed bi-compartmental elimination from the rabbit brain with half-lives (t 1/2 of 25 and 320 mins for halothane and 26 and 174 mins for isoflurane).…”
Section: Other Drugs: Retention Of Anestheticsmentioning
confidence: 98%
“…It does seem clear, however, that halothane is detectable in the brain using IgF MRS up to 90 min after a relatively short anesthetic. Previous animal studies that have addressed this issue are in conflict; although some studies have shown that halothane is detectable in mousehat brain up to 6.5 h after a relatively prolonged anesthetic with halothane (5), other authors have reported that halothane retention in the brain is much less prolonged (6), and there is evidence to suggest that some of the more persistent signal may have arisen from trifluoroacetate (15). The use of "F MRS to obtain precise pharmacokinetic data will require better volume localization.…”
Section: In Vivo 19f Mrs Of Halothane In Postoperative Patientsmentioning
confidence: 91%
“…During the whole examination, the animals were kept in an injection narcosis using 5 mg/kg body weight of xylazine hydrochloride (Rompun@, Bayer, Leverkusen, Germany) and 125 mg/kg body weight of ketamine (Ket-anest@, Parke Davis, Berlin, Germany), given by an intramuscular injection. In contrast with fluorinated inhalation anaesthetics such as halothane or enflurane, which give rise to strong "F MR signals (22)(23)(24), the anesthetic agents used in our study are free of fluorine. Consequently, there is no interference with the "F MR signal of 5-FU and its metabolites.…”
Section: Animal Studymentioning
confidence: 96%
“…In contrast with fluorinated inhalation anaesthetics such as halothane or enflurane, which give rise to strong "F MR signals (22)(23)(24), the anesthetic agents used in our study are free of fluorine. Consequently, there is no interference with the "F MR signal of 5-FU and its metabolites.…”
Section: Animal Studymentioning
confidence: 98%