Determination of HCV genotypes and viral loads in chronic HCV infected patients of Hazara Pakistan

Ali, Amjad; Nisar, Muhammad; Ahmad, Habib; Saif, Nausheen; Idrees, Muhammad; Bajwa, Mohammad A

doi:10.1186/1743-422x-8-466

Cited by 46 publications

(48 citation statements)

References 36 publications

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“…This study ascertained that HCV genotypes were spread with equal probability between the both sexes and there was no association between gender and HCV genotypes. These results are in agreement with multiple previous studies indicating little statistical association between genders and genotypes in Pakistan (8,(10)(11)(12). This study contradicts a Libyan study that showed the association of various HCV genotypes with gender (13).…”

Section: Discussionsupporting

confidence: 94%

“…This study also reported many rare genotypes like 5a, 1c, and 6a, which are uncommon and less reported. Unlike Ali et al (8) sudy findings, the findings of this study support the verdict of some previous studies that showed the presence of genotypes such as 5a, 4a, and 1c in spite of their rare status (9)(10)(11)16). These findings are in contradiction with those of some studies that have shown the partial absence of genotypes 4, 5, and 6 (8,17).…”

Section: Discussioncontrasting

confidence: 92%

“…As determined in the past studies, HCV RNA titer was categorized into three levels based on their specified values as low level (< 600,000 IU/mL), intermediate level (600,000 -800,000 IU/mL), and high level (> 800,000 IU/mL) (8). Genotype 3 HCV-infected patients falling in the low level RNA titer category i.e.…”

Section: Discussionmentioning

confidence: 99%

“…This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. lence of HCV genotypes (7,8), not much data is available regarding the correlation between hemato-biochemical values, viral load, and HCV genotypes. Therefore, the present study emphasizes the distribution of different HCV genotypes, pretreatment hemato-biochemical analysis, and HCV RNA viral load in HCV infected patients in Rahim Yar khan, Okara, and Toba Tek Singh districts of Punjab province, Pakistan, which are most neglected areas of this region.…”

Section: Introductionmentioning

confidence: 99%

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Distribution of HCV Genotypes and RNA Viral Load Along with Hemato-Biochemical Analysis of HCV Patients in Rahim Yar Khan, Okara and Toba Tek Singh Districts of Punjab, Pakistan

et al. 2017

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Background: HCV has very diverse genotypes in nature, divided into variable number of subtypes. Due to epidemiologically divergent subtypes, it shows diverse geographical distributions, which makes it difficult to treat. This disease plays havoc with underdeveloped and developing countries due to scarcity of data and poor awareness among common people. Therefore, this study aimed to evaluate the geographical distribution of HCV genotypes and RNA viral load along with hemato-biochemical analysis of HCV patients in underdeveloped and neglected areas of Punjab province, Pakistan.

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Section: Discussionsupporting

confidence: 94%

Section: Discussioncontrasting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Distribution of HCV Genotypes and RNA Viral Load Along with Hemato-Biochemical Analysis of HCV Patients in Rahim Yar Khan, Okara and Toba Tek Singh Districts of Punjab, Pakistan

et al. 2017

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“…11,18 A study conducted at Pakistan in 2011 showed a significant higher HCV viral load in genotype 1 as compared to other genotypes. 19 A similar kind of study done in India also showed that viral load in patients with genotype 1 was significantly higher than other HCV genotypes.…”

Section: Discussionmentioning

confidence: 79%

Clinical, Biochemical and Virological Profile of Patients with Chronic Hepatitis C Virus Infection - A Study from University Hospital in Nepal

Gurubacharya

Khadka²,

Shreshta³

et al. 2015

J Nobel Med Coll

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Introduction: Hepatitis C virus (HCV) infection is a major public health challenge. It is a major cause for cirrhosis and hepatocellular carcinoma worldwide. Both the genotype and viral load of HCV determine the choice of therapy as well as outcome of therapy. The aim of this study was to evaluate clinical, biochemical and virological profile and association of HCV genotypes with viral load and liver biochemical profile. Material and Methods:This was descriptive observational study of chronic HCV infected patients who attended at the outpatient clinic of Department of Gastroenterology of TUTH, IOM from April 2013 to November 2014. During this study period 38 patients with chronic HCV infection were analyzed. Clinical profile, possible risk factors for transmission of HCV infection and liver biochemical profile were recorded. Virological profile included HCV viral load and HCV genotypes. Results:Out of 38 patients 34(89.5%) were male and 4(10.5%) were female. Injection drug use (IDU) was the most common mode for acquisition of HCV infection (55.3%). Genotype 3 was found in 21(55.26%) patients and genotype 1 was found in 17(44.74%) patients. There was no significant association between HCV genotypes and serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level. And also there was no significant association between HCV viral load and different HCV genotypes. Conclusions:In our study HCV genotype 3 was the most prevalent genotype in patients with chronic HCV infection. Injection drug use was identified as most common identifiable risk factor for transmission of HCV infection. There was no significant association between different HCV genotypes and serum ALT, AST level and HCV viral load.

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Direct‐acting antiviral therapy for chronic hepatitis C among incarcerated people who inject drugs

Mao

Chen

2022

Adv in Digestive Medicine

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Hepatitis C virus (HCV) infection is an important public health problem, causing significant morbidity and mortality worldwide. The prevalence of HCV infections is especially high among people who inject drugs (PWID). The efficacy of direct‐acting antiviral (DAA) therapy was evaluated herein. During 2019‐2021, a total of 321 cases who received a full course of DAA therapy and completed a 12‐week follow‐up observation were studied. The most frequent genotype (GT) was GT6 (34.9%), followed by GT1a (23.4%), GT1b (14.6%), GT2 (12.1%), and GT3 (11.8%). Increase was observed in GT6 (from 29.8% in 2019 to 44.9% in 2021) and GT3 (from 9.9% in 2019 to 16.3% in 2021) over the study years. GT2 was more likely found in patients >50 years old, while GT3 was more in younger patients (both P < .05). GT3 was also more frequently associated with moderate scores of fibrosis‐4 index (FIB‐4) (1.45 ≤ FIB‐4 ≤ 3.25, 13/38 vs 49/283; P < .05). High viral loads (>1 500 000 IU/mL) were found in 65.7% of the patients, including 21.5% showing a very high level (>6 000 000 IU/mL). Compared to other genotypes, viral loads were significantly higher in GT6 (P < .005) and lower in GT1b (P < .01). The end of treatment virologic response rate and the sustained virologic response rate at 12 weeks (SVR12) post‐treatment were both 100%. Two recurrent infections with GT6 and GT2 were noted at 16‐month and 3‐month, respectively, after achieving SVR12. The present report provides a solid evidence for the effectiveness of DAA therapy in the treatment of hepatitis C among incarcerated PWID. We believe that appropriate DAA therapy, when incorporated with active universal screening, can achieve micro‐elimination of chronic hepatitis C in incarcerated persons. Hence, the strategies should be applied to all custodial settings, especially for PWID, as an important step to eliminate hepatitis C by 2025, a goal set by the Taiwan government.

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Determination of HCV genotypes and viral loads in chronic HCV infected patients of Hazara Pakistan

Cited by 46 publications

References 36 publications

Distribution of HCV Genotypes and RNA Viral Load Along with Hemato-Biochemical Analysis of HCV Patients in Rahim Yar Khan, Okara and Toba Tek Singh Districts of Punjab, Pakistan

Distribution of HCV Genotypes and RNA Viral Load Along with Hemato-Biochemical Analysis of HCV Patients in Rahim Yar Khan, Okara and Toba Tek Singh Districts of Punjab, Pakistan

Clinical, Biochemical and Virological Profile of Patients with Chronic Hepatitis C Virus Infection - A Study from University Hospital in Nepal

Direct‐acting antiviral therapy for chronic hepatitis C among incarcerated people who inject drugs

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