Determination of hepatic fractional clearance of radioactive gold colloids for a measure of effective hepatic blood flow

Fujii, Masahiro; Yamamoto, Tetsuro; Wakisaka, Gyoichi

doi:10.1016/0047-0740(79)90060-3

Cited by 7 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…29 examinations of patients without any disturbance of liver function or metabolism showed a Normotest mean value of 91.6 t 16.7%. To measure effective hepatic blood flow, hepatic fractional clearance of l,8Au-colloid was determined from the disappearance rate multiplied by the fraction of the injected dose taken up by the liver as measured with a 7-camera (2). Serum albumin, globulin and SGPT (IU/1) were determined at the Central Clinical Laboratory Division of Kyoto Universi ty Hospital.…”

Section: Methodsmentioning

confidence: 99%

Correlation Analysis of Relationships between Vitamin-K-Dependent Clotting Factors and Effective Hepatic Blood Flow, Albumin and Other Liver Function Tests

Fujii¹,

Yasunaga²,

Uchino³

1980

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

Relationships between Normotest, prothrombin time, albumin, γ-globulin, GPT, and the hepatic fractional clearance of ¹⁹⁸Au-colloids as a measure of effective hepatic blood flow were studied by correlation analysis, in 50 patients with liver diseases, including chronic hepatitis or cirrhosis. Simple correlation coefficients were highly significant between Normotest, prothrombin time, albumin, and the heaptic fractional clearance; however, not between GPT or γ-globulin and the other parameters. Further correlation analysis revealed a highly significant partial correlation coefficient between Normotest and albumin and the hepatic clearance; however, not between Normotest and albumin. As effective hepatic blood flow is considered to be proportional to the liver parenchymal volume, the above results indicate that vitamin-K-dependent clotting factors, as well as albumin, reflect the liver cell mass.

show abstract

Section: Methodsmentioning

confidence: 99%

Correlation Analysis of Relationships between Vitamin-K-Dependent Clotting Factors and Effective Hepatic Blood Flow, Albumin and Other Liver Function Tests

Fujii¹,

Yasunaga²,

Uchino³

1980

Pathophysiol Haemos Thromb

View full text Add to dashboard Cite

show abstract

“…the disappearance rate or tissue distribution are not always the same in different individuals. 5 Although Au-198 colloid is a nuclide of high energy and has a half life of 2.7 days, Au-198 colloid seemed to be more sensitive and suitable for the measurement of hepatic blood flow by the clearance method than Tc-99m sulfur colloid or Tc-99m phytate. 5,6 Our previous animal experiments revealed that hepatic blood flows of normal adult mongrel dogs measured by Au-198 colloid, KICG and H2 clearance methods significantly correlate with each other.…”

Section: Discussionmentioning

confidence: 99%

“…5 Although Au-198 colloid is a nuclide of high energy and has a half life of 2.7 days, Au-198 colloid seemed to be more sensitive and suitable for the measurement of hepatic blood flow by the clearance method than Tc-99m sulfur colloid or Tc-99m phytate. 5,6 Our previous animal experiments revealed that hepatic blood flows of normal adult mongrel dogs measured by Au-198 colloid, KICG and H2 clearance methods significantly correlate with each other. 7,12 Several authors reported on K value determination using liver accumulation curve analysis of Au-198 colloid (Dobson2 0.284, Veter3 0.236, Iio4 0.146).…”

Section: Discussionmentioning

confidence: 99%

“…The disappearance rate was thought to be a measure of minimum hepatic blood flow. [2][3][4][5][6] The selection of an appropriate radiocolloid is one problem. It has been pointed out that the particle size of the radiocolloid should not only be uniform and suitable for measuring hepatic blood flow, but also that extrahepatic removal should be minimal.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7] As an accumulation of radiocolloid reflects the reticuloendothelial function, we expressed it in terms of effective residual liver or effective liver volume. There are several reports concerning volume estimation by means of liver scintigraphy.S - 11 We devised an original method in which effective liver volume was measured by scintigraphy.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical values for an index predicting postoperative residual liver function by pre-operative liver-scintigraphy in patients with liver disease

et al. 1989

View full text Add to dashboard Cite

Hepatic resection is essential in treating hepatocellular carcinoma. However, before an operation, it is difficult to predict the functional reserve in the remnant following massive resection. We devised an original method by which effective liver volume was measured by liver scintigraphy. In order to predict the residual liver function before hepatic resection in a preoperative radiocolloid study, we obtained a predictive index by combining the K values with effective liver volumes which seemed to have the estimated residual liver function. Twenty-one patients with liver or biliary tract disease were selected at random for the present study. We divided them into 3 groups in accordance with prognosis after hepatic resection. There were statistically significant difference between the deceased group who died from hepatic failure and the group who died from causes other than hepatic failure; and between the deceased group who died from hepatic failure and the living group in the preictive index (p less than 0.01). Our data suggest that if the predictive index is above 0.45, the probability of hepatic failure after hepatic resection is low. We concluded that our predictive index is useful to use in preoperative prediction of post-hepatectomic residual liver function.

show abstract

Determination of the extent of feasible hepatic resection from hepatic blood flow

et al. 1986

View full text Add to dashboard Cite

Blood flow in the residual liver after major hepatectomy is considered an important determinant factor of liver function. Presented here is a method of obtaining the whole and regional hepatic blood flow index from hepatic clearance of 19SAu-colloid, which can predict the blood flow index of residual liver before operation and thereby prevent postoperative hepatic failure due to too large a resection. Hepatic resection was followed by a decrease of the hepatic blood flow index (KLAu) almost proportional to the amount of hepatic mass resected. An analysis of data from 34 patients who underwent hepatectomy showed that the preoperatively predicted value of the blood flow index in the unresected liver had a good correlation (r = 0.9) with that measured 1 month after hepatectomy. It also correlated well with the risk of death from liver failure among those patients whose KL value of residual liver was under the critical level. Since 1981 the early death rate from liver failure after hepatectomy was reduced remarkably by preparing the resection boundary on the basis of the blood flow index of residual liver. With the use of our method in animal experiments, the hepatic blood flow index was found to be uninfluenced by reticuloendothelial system function and was considered to be a reliable indicator of blood flow in hepatic sinusoids.

show abstract

Determination of hepatic fractional clearance of radioactive gold colloids for a measure of effective hepatic blood flow

Cited by 7 publications

References 7 publications

Correlation Analysis of Relationships between Vitamin-K-Dependent Clotting Factors and Effective Hepatic Blood Flow, Albumin and Other Liver Function Tests

Correlation Analysis of Relationships between Vitamin-K-Dependent Clotting Factors and Effective Hepatic Blood Flow, Albumin and Other Liver Function Tests

Clinical values for an index predicting postoperative residual liver function by pre-operative liver-scintigraphy in patients with liver disease

Determination of the extent of feasible hepatic resection from hepatic blood flow

Contact Info

Product

Resources

About