Determination of heroin by circular dichroism

Abstract

A method of analysis for heroin Is described In which separation of the drug Is not a prerequisite to Its quantitative determination. The normally encountered diluents and adulterants present In confiscated samples do not exhibit the phenomenon of circular dichroism and are noninterfering. Analysis Is uncomplicated, quick, and easily reproducible. Correspondence with determinations which used gas chromatography Is better than 1 %.

Direct determination of .beta.-lactam antibiotics by circular dichroism

“…A large number of papers dealing with optical sensors has been published recently, among them articles describing 0003-2700/87/0359-1351$01.50/0 various optical pH probes (optrodes or optodes) figure prominently (1)(2)(3)(4)(5)(6). The main reasons cited for development of optical sensors are the lack of necessity of a reference electrode and electrical safety.…”

“…The degree of selectivity has been sufficient in a number of cases to determine an analyte without any chromatographic separation of the sample, or any other kind of workup, except a simple extraction into a recommended solvent system. Examples of single analytes successfully analyzed in this way are (-)-cocaine (4), heroin (5), and (+)-LSD (6). More complex systems containing more than one CDactive analyte have also been successfully determined, the most impressive among these being plant extracts (7).…”

Determination of nicotine in tobacco by circular dichroism spectropolarimetry

“…Recently, a new method (7) for ETO was developed by OSHA at their Salt Lake City Laboratory. Samples are collected by using two charcoal tubes connected in series and desorbed with 1% CS2 in benzene.…”

“…Circular dichroism (CD) spectropolarimetry has been successfully applied to the identification and determination of alkaloids in a variety of complex matrices (1)(2)(3)(4)(5)(6)(7)(8). Since two prerequisites must be satisfied for CD activity, namely, the analyte must simultaneously absorb electromagnetic radiation and be optically active, determinations can be made quickly and directly, after simple solvent extraction and without separation from the other components in the mixture.…”

Pharmaceuticals and related drugs

“…Wyatt et al (27) have reviewed the physical properties, synthesis, stability, metabolism, and analysis of heroin. Analysis and identification of heroin and related opiates have been accomplished by a variety of techniques such as mass spectrometry (MS) (28), highperformance liquid chromatography (HPLC) {29-37), GC (38, 39), thin-layer chromatography (TLC) (40,41), nuclear magnetic resonance (NMR) (42,43), and circular dichroism (44,45). Also, Schwartz et al (46) have used a glassy carbon electrode for the voltrammetric determination of morphine in poppy straw concentrate.…”