Determination of heterogeneous thermal parameters using ultrasound induced heating and MR thermal mapping

Huttunen, Janne M. J.; Huttunen, Tomi; Malinen, Matti; Kaipio, Jari P.

doi:10.1088/0031-9155/51/4/017

Cited by 31 publications

(36 citation statements)

References 62 publications

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“…In three dimensions, there is more versatility in the placement of the elements, so that achieving the desired focus in the tissue is actually easier [43]. This discussion shows that if the treatment is predicted to be safe in two dimensions, the actual three-dimensional treatment is likely to be safe as well.…”

Section: Limitations Of This Studymentioning

confidence: 98%

Finite-element simulation of ultrasound brain surgery: effects of frequency, focal pressure, and scanning path in bone-heating reduction

et al. 2008

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Abstract:In this paper, the finite-element method (FEM) simulation of ultrasound brain surgery is presented. The overheating problem of the post-target bone, which is one of the limiting factors for a successful ultrasound brain surgery, is considered. In order to decrease bone heating, precise choices of frequency, focal pressure, and scanning path are needed. The effect of variations in the mentioned scanning parameters is studied by means of the FEM. The resulting pressure and temperature distributions of a transdural ultrasound brain surgery are simulated by employing the FEM for solving the Helmholtz and bioheat equations in the context of a two-dimensional MRI-based brain model. Our results show that for a suitable value of the frequency, an increase in focal pressure leads to a decrease in the required duration of the treatment and is associated with less heating of the surrounding normal tissue. In addition, it is shown that at a threshold focal pressure, the target temperature reaches toxic levels whereas the temperature rise in the bone is minimal. Wave reflections from sinus cavities, which result in constructive interference with the incoming waves, are one of the reasons for overheating of the bone and can be avoided by choosing a suitable scanning path. PACS

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Section: Limitations Of This Studymentioning

confidence: 98%

Finite-element simulation of ultrasound brain surgery: effects of frequency, focal pressure, and scanning path in bone-heating reduction

et al. 2008

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“…2. Based on this study, we have developed our collaboration relationship with two research groups at the University of Cincinnati: Dr. Donald French's group [1][2] and Dr. Christy Holland's group [3]. Dr. French is working on inverse imaging problem for HIFU treatment planning and Dr. Holland is working on cavitation mechanisms in cardiac applications of HIFU.…”

Section: Reportable Outcomesmentioning

confidence: 99%

“…Introduction: Magnetic Resonance (MR) is routinely used to monitor thermal therapy in clinical applications of High Intensity Focused Ultrasound (HIFU). MR-thermometry typically relies on changes in signal phase arising from the proton resonance frequency (PRF) sensitivity to temperature [1][2]. Little attention has been paid to MR signal magnitude dependencies on temperature.…”

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confidence: 99%

MR-Guided Focused Ultrasound Ablation of Visceral Fat: A new treatment for metabolic syndrome

Dumoulin¹

2018

Preprint

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I am writing to provide you and the Foundation the final report on the execution of the project entitled "MR-Guided Focused Ultrasound Ablation of Visceral Fat: A new treatment for metabolic syndrome". BackgroundThe overarching goal of the research is to develop a non-invasive approach for the treatment of metabolic syndrome. The main hypothesis of the project is that HIFU ablation of visceral fat can improve insulin action in obese rats and provide a non-invasive treatment for type 2 diabetes and other diseases associated with metabolic syndrome. The hypothesis is being tested with two specific aims that are centered on: 1) technique development, and 2) animal experiments.We estimate that the entire research program will cost approximately $500,000 to conduct, and we are grateful to the Focused Ultrasound Foundation for the grant of $100,000 which allowed us to purchase the equipment. At this point we are still seeking funds to cover the remainder of the metabolic syndrome project, but as you can see from the progress reported below, the hardware that has been acquired with the support from your foundation has given us a tremendous start. We have made significant progress on aim 1 and, the grant has enabled exciting new programs in other directions relevant to human disease. Progress1) We ordered a pre-clinical Sonalleve MR-guided HIFU system from Philips in early 2011. The system was delivered in late 2011. The system is now operational and being used on our 3T MR system. All animal experiments have been performed under animal use protocols.2) The HIFU system has been optimized for use on rats with the creation of a new stage and MR imaging coils.3) We have developed high-speed imaging approaches for monitoring temperature changes and thermal dose. One of the approaches we are investigating is the use of magnitude images for temperature monitoring. 4)We have used the system to support simple ablations in pig livers in collaboration with Dr. Rupak Banerjee at the University of Cincinnati. 7) The progress with the preclinical HIFU system has encouraged us to pursue human research opportunities. We have secured funding from our institution to purchase a clinical Sonalleve system from Philips to perform clinical HIFU treatments and related research. Our first clinical target will be bone ablation in pediatric patients. The preclinical and clinical systems will have common control software and we anticipate substantial benefit for translational studies.8) Several publications describing our HIFU experimental results are in preparation. This includes an abstract for presentation at next year's ISMRM.Additional details of our progress can be found in the attached documents. We at Cincinnati Children's Medical Center are very grateful for the support the FUS Foundation has provided and we look forward to the research opportunities it enables as we pursue our mission of improving the practice of healthcare for our patients.Please feel free to call me if you have any questions. Introduction: Magnetic Resonance (MR) is r...

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“…2. Based on this study, we have de veloped our collaboration relationship with two research groups at the University of Cincinnati: Dr. Donald French's group [1][2] and Dr. Christy Holland's group [3]. Dr. French is working on inverse imaging problem for HIFU treatme nt planning and Dr. Holland is wor king on cavitation mechanisms in cardiac application s of HIFU.…”

Section: Key Research Accomplishmentsmentioning

confidence: 99%

Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas

Liu¹

2012

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Determination of heterogeneous thermal parameters using ultrasound induced heating and MR thermal mapping

Cited by 31 publications

References 62 publications

Finite-element simulation of ultrasound brain surgery: effects of frequency, focal pressure, and scanning path in bone-heating reduction

Finite-element simulation of ultrasound brain surgery: effects of frequency, focal pressure, and scanning path in bone-heating reduction

MR-Guided Focused Ultrasound Ablation of Visceral Fat: A new treatment for metabolic syndrome

Non-invasive MR-guided HIFU Therapy of TSC-Associated Renal Angiomyolipomas

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