Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications

Liu, Yu; Yuan, Wei; Fang, Miao; Guo, Huimin; Zhang, Xin; Xue, Mei; Zhang, Yuyi; Ji, Long-Shan; Gao, Yating; Wang, Jiefei; Qian, Zhiping; Li, Man; Gao, Yueqiu

doi:10.3389/fphar.2022.1031790

Cited by 3 publications

(1 citation statement)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatitis B cirrhosis, triggered by the prolonged infection of hepatitis B virus, is related to AKI in cirrhotic patients. 20 , 21 For lipid and atherosclerosis, atherosclerosis has a relationship with chronic kidney disease. 22 Lipid accumulation may subsequently develop into lipotoxicity, which further induces pathological injury in proximal tubular cells.…”

Section: Discussionmentioning

confidence: 99%

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis

Xi,

Zhang,

et al. 2023

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis

Xi,

Zhang,

et al. 2023

Molecular Therapy - Nucleic Acids

View full text Add to dashboard Cite

Editorial: Tissue regeneration using dental stem cells

Tatullo,

Ellis,

Islam

2024

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Editorial on the Research Topic Tissue regeneration using dental stem cells Tissue regeneration is a multidisciplinary field that combines various aspects of biology, medicine, materials science, and engineering. The three main pillars of tissue engineering are: biomimetic biomaterials, growth factors able to drive cell fate, and, most importantly, stem cells. The complex interaction between resident stem cells and the local environment is a multifactorial process, regulated by multiple pathways able to actively influence a wide range of biological processes, from cell division to multilineage differentiation (Santilli et al.).In this landscape, several studies have undoubtedly demonstrated that dental and periodontal tissues contain a significant amount of highly immature mesenchymal stem cells (MSCs). Dental MSCs (DMSCs) have been found in various dental tissues; moreover, DMSCs have gained growing interest from the scientific community because of their easy accessibility, and thanks to their high strategic plasticity both in dental tissues repair and in regenerating several types of human tissues, including bone, cartilage, muscle, and neural tissue. Despite oral tissues not being the most used niches of MSCs, we should carefully rethink the role of DMSCs in tissue regeneration, as their use may lead to a significant advance of knowledge in regenerative dentistry, impacting on the future treatments of various systemic diseases (Namjoynik et al., 2023;Tatullo et al., 2023).This Research Topic has investigated a wide range of Research Topic, confirming the valuable potentialities of DMSCs in tissue regeneration. Several approaches have been proposed to optimize and enhance the regenerative potential of MSC, such as the use of media conditioned with different growth factors, or cytokines and bioactive molecules (Liu et al., 2022;Ueda et al., 2022). However, these biological strategies alone were deemed not to have reached their potential in some specific clinical conditions (Chouaib et al., 2022); thus, the researchers have added physical factors to improve cell proliferation. Using this premise, studies on various light sources, including LASERs and light-emitting diode (LED), were reviewed, and indicated that photo-biomodulation could be a good aid in those regenerative protocols aimed at stimulating periodontal ligament stem cells (PDLSCs) to repair damaged dental tissues. However, the review revealed that there were a lot of ambiguity in these protocols and could have a conflict of interests as they were funded by the LASER companies (Ponnaiyan et al.).

show abstract

Sphagnum cuspidatulum extract prevents acute kidney injury induced by high-fat diet and streptozotocin via alleviation of oxidative stress and apoptosis in pre-diabetic rats

Laorodphun,

Chaisen,

Amattat

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

ContextObesity and pre-diabetes are associated with renal dysfunction via elevated oxidative stress. Peat moss, or Sphagnum cuspidatulum Müll. Hal., Sphagnaceae (SC), are rich in phenolic compounds that enhance antioxidant activity.ObjectiveSC might show beneficial effects in pre-diabetes-associated renal dysfunction.Materials and methodsMale Wistar rats, after 4 weeks on a high-fat diet, received low-dose streptozotocin to induce pre-diabetes. Then, the pre-diabetic rats were randomly divided into 4 groups: untreated pre-diabetic rats (P-DM), pre-diabetic rats treated with SC 50 or 100 mg/kg/day (P-DM50 or P-DM100), and pre-diabetic rats treated with metformin 100 mg/kg/day (MET). The drugs were fed by gavage for 4 weeks.ResultsTreatment with SC100 dramatically lowered serum creatinine (S.Cr.), blood urea nitrogen (BUN), and augmented creatinine clearance in pre-diabetic rats. Additionally, SC100 significantly decreased the malondialdehyde level. Furthermore, pre-diabetic rats treated with SC100 significantly upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream mediators, with downregulated apoptotic markers.Discussion and conclusionOur findings provide a scientific basis for the clinical application of SC and a new strategy for the prevention of nephrotoxicity and other kidney disease in the future.

show abstract

Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications

Cited by 3 publications

References 45 publications

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis

Unveiling the mechanisms of nephrotoxicity caused by nephrotoxic compounds using toxicological network analysis

Editorial: Tissue regeneration using dental stem cells

Sphagnum cuspidatulum extract prevents acute kidney injury induced by high-fat diet and streptozotocin via alleviation of oxidative stress and apoptosis in pre-diabetic rats

Contact Info

Product

Resources

About