Determination of Hydrogen Sulfide in Wines Based on Chemical-Derivatization-Triggered Aggregation-Induced Emission by High-Performance Liquid Chromatography with Fluorescence Detection

Yu, Yanxin; Li, Guoliang; Wu, Di; Zheng, Fuping; Zhang, Xianlong; Liu, Jianghua; Hu, Na; Wang, Honglun; Wu, Yongning

doi:10.1021/acs.jafc.9b04454

Cited by 34 publications

(19 citation statements)

References 41 publications

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“…The proposed Fe 3 O 4 @COF(TpBD)/TiO 2 based MSPE coupled with HPLC‐MS/MS for EDC detection was validated under the optimized MSPE conditions. Several key parameters including linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy and precision were investigated 35–37 . Furthermore, enrichment factors (EFs) were calculated to evaluate the efficiency of the extraction procedure.…”

Section: Methodsmentioning

confidence: 99%

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

Liu

et al. 2020

J Sci Food Agric

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BACKGROUND Endocrine disrupting chemicals (EDCs), proved to be potential carcinogenic threats to human health, have received great concerns in food field. It was essential to develop effective methods to detect EDCs in food samples. The present study proposed an efficient method to determine trace EDCs including estrone (E1), 17β‐estradiol (E2), estriol (E3) and bisphenol A (BPA) based on magnetic solid‐phase extraction (MSPE) coupled high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS/MS) in meat samples. RESULTS Fe3O4@COF(TpBD)/TiO2 nanocomposites were synthesized via functionalization of magnetic covalent organic frameworks (COFs) with titanium dioxide (TiO2) nanoparticles, and used as absorbents of MSPE to enrich EDCs. The efficient EDCs enrichment relies on π–π stacking interaction, hydrogen bonding, and the interaction between titanium ions (IV, Ti4+) and hydroxyl groups in EDCs, which improves the selectivity and sensitivity. Under the optimized conditions, target EDCs were rapidly extracted through MSPE with 5 min. Combining Fe3O4@COF(TpBD)/TiO2 based MSPE and HPLC‐MS/MS to determine EDCs, good linearities were observed with correlation coefficient (R2) ≥ 0.9989. The limits of detection (LODs) and limits of quantification (LOQs) were 0.13–0.41 μg kg−1 and 0.66–1.49 μg kg−1, respectively. Moreover, the proposed method was successfully applied to real samples analysis. CONCLUSIONS The established MSPE‐HPLC‐MS/MS method was successfully applied to determine EDCs in meat samples with rapidness, improved selectivity and sensitivity. It shows great prospects for EDCs detection in other complicated matrices. © 2020 Society of Chemical Industry

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Section: Methodsmentioning

confidence: 99%

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

Liu

et al. 2020

J Sci Food Agric

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“…Upon addition of H 2 S, precipitation of CuS occurred due to the high affinity between Cu 2+ and S 2− , leading to recovery of fluorescence, which was utilized for monitoring mitochondrial H 2 S in HeLa cells. Inspired by AIEgens widely used in fluorescence bioimaging and theranostics, in 2019, Li and coworkers rationally developed a low‐cost AIE‐active fluorescent probe 11 for highly selective sensing of H 2 S. [ 68 ] In aqueous solution, a chemical‐derivatization‐triggered AIE approach by H 2 S induced a specific AIE fluorescence at 475 nm, which sharply red‐shifted compared with monomer probe 11 (375 nm). Probe 11 displayed a high sensitivity toward H 2 S with a detection limit of 0.25 nM in a wine‐beer sample and 0.30 nM in a red wine sample.…”

Section: Aiegens For Analysis Of Small Moleculesmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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“…To date, the most commonly used methods for detection of H 2 S include high-pressure liquid chromatography 16 , gas chromatography 17 , electrochemical analysis 18 , and methylene blue assay 19 , etc. These approaches display great detecting sensitivity in the order of nanomole.…”

Section: Introductionmentioning

confidence: 99%

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

Zhang

Fang

et al. 2022

Nat Commun

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Hydrogen sulfide (H2S) as an important biological gasotransmitter plays a pivotal role in many physiological and pathological processes. The sensitive and quantitative detection of H2S level is therefore crucial for precise diagnosis and prognosis evaluation of various diseases but remains a huge challenge due to the lack of accurate and reliable analytical methods in vivo. In this work, we report a smart, H2S-responsive and depleting nanoplatform (ZNNPs) for quantitative and real-time imaging of endogenous H2S for early diagnosis and treatment of H2S-associated diseases. We show that ZNNPs exhibit unexpected NIR conversion (F1070 → F720) and ratiometric photoacoustic (PA680/PA900) signal responsiveness towards H2S, allowing for sensitive and quantitative visualization of H2S in acute hepatotoxicity, cerebral hemorrhage model as well as colorectal tumors in living mice. ZNNPs@FA simultaneously scavenges the mitochondrial H2S in tumors leading to significant ATP reduction and severe mitochondrial damage, together with the activated photodynamic effect, resulting in efficient suppression of colorectal tumor growth in mice. We believe that this platform may provide a powerful tool for studying the vital impacts of H2S in related diseases.

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Determination of Hydrogen Sulfide in Wines Based on Chemical-Derivatization-Triggered Aggregation-Induced Emission by High-Performance Liquid Chromatography with Fluorescence Detection

Cited by 34 publications

References 41 publications

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

Highly sensitive determination of endocrine disrupting chemicals in foodstuffs through magnetic solid‐phase extraction followed by high‐performance liquid chromatography‐tandem mass spectrometry

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

A hydrogen sulphide-responsive and depleting nanoplatform for cancer photodynamic therapy

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