In this study, fluidized-bed Fenton process (FBF) was used to degrade dimethyl sulfoxide (DMSO), one of the most widely used solvents. Oxidation by Fenton's reagent, Fe ?2 and H 2 O 2 , is one of the cheapest advanced oxidation processes due to the high availability of the reagents. FBF is a modified approach that reduces the large amount of iron oxide sludge formed in conventional Fenton process. The optimal treatment efficiencies by FBF with 2 h of reaction were 95.22 % of DMSO degradation and 34.38 % of COD removal at the conditions of 5 mM DMSO, 68.97 g/L SiO 2 carrier, pH initial 3.0, 5 mM Fe 2? , and 32.5 mM H 2 O 2 . The kinetic study was also done to investigate the two stages involved in the oxidation. The first stage fitted the zero reaction order with overall initial rate's apparent rate constant, k 1 , of -0.099. The second stage fitted the first order of DMSO degradation, with rate constant, k 2 , of -0.0005.