Determination of Hymexazol in Cucumber and Soil Samples by Derivatization Using GC-FPD

Sun, Dianjun; Li, Li; Ji, Ran; Li, Wei; Ye, Huo-Chun; Wu, Yi‐Jun; Liu, Chenglan

doi:10.1007/s00128-011-0421-x

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…Hymexazol (Ref: F 319, Figure 1 ) is also an effective but less toxic broad-spectrum fungicide recommended for use against gray mold, late blight , Fusarium wilt, damping-off, anthracnose in vegetables, rice, cotton, fruit, tobacco crops, soybean, etc. [ 21 , 22 , 23 , 24 ]. It can be absorbed directly by plant roots, transferred quickly to multiple parts of the plant, and then transformed into two glucosides ( O -glucoside and N -glucoside).…”

Section: Introductionmentioning

confidence: 99%

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase

Antypenko

Meyer

Sadyk

et al. 2023

JoF

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Agents with antifungal activity play a vital role as therapeutics in health care, as do fungicides in agriculture. Effectiveness, toxicological profile, and eco-friendliness are among the properties used to select suitable substances. Furthermore, a steady supply of new agents with different modes of action is required to counter the well-known potential of human and phyto-pathogenic fungi to develop resistance against established antifungals. Here, we use an in vitro growth assay to investigate the activity of the calcineurin inhibitor tacrolimus in combination with the commercial fungicides cyproconazole and hymexazol, as well as with two earlier reported novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines, against the fungi Aspergillus niger, Colletotrichum higginsianum, Fusarium oxysporum and the oomycete Phytophthora infestans, which are notoriously harmful in agriculture. When tacrolimus was added in a concentration range from 0.25 to 25 mg/L to the tested antifungals (at a fixed concentration of 25 or 50 mg/L), the inhibitory activities were distinctly enhanced. Molecular docking calculations revealed triazole derivative 5, (2-(3-adamantan-1-yl)-1H-1,2,4-triazol-5-yl)-4-chloroaniline), as a potent inhibitor of chitin deacetylases (CDA) of Aspergillus nidulans and A. niger (AnCDA and AngCDA, respectively), which was stronger than the previously reported polyoxorin D, J075-4187, and chitotriose. The results are discussed in the context of potential synergism and molecular mode of action.

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Section: Introductionmentioning

confidence: 99%

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase

Antypenko

Meyer

Sadyk

et al. 2023

JoF

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Inclusion Complexes of Hymexazol with Three Different Cucurbit[n]uril: Preparation, and Physicochemical and Antifungal Characterization

Fan

Gao

Xiao

et al. 2018

Israel Journal of Chemistry

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Host‐guest inclusion complexes of hymexazol with three different cucurbit[n]uril, cucurbit[7]uril (Q[7]), hemimethyl‐substituted cucurbit[6]uril (HHMeQ[6]), and twisted cucurbit[14]uril (tQ[14]) have been investigated by means of 1H NMR spectroscopy, quadrupole‐time of flight mass spectrometry (Q‐TOF), and isothermal titration calorimetry (ITC). 1H NMR experimental results revealed that hymexazol resides within the respective cavities of the selected Q[n], and mass spectrometric experimental results revealed that it interacts with these three Q[n] through the formation of 1 : 1 inclusion complexes. ITC experimental results indicated moderate binding constants. In vitro assays showed that the complexation of hymexazol by the Q[n] increased its inhibitory effect on the mycelia growth of Botrytis cinerea Pers.

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Determination of hymexazol in 26 foods of plant origin by modified QuEChERS method and liquid chromatography tandem-mass spectrometry

Jiang

Cao

et al. 2017

Food Chemistry

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Determination of Hymexazol in Cucumber and Soil Samples by Derivatization Using GC-FPD

Cited by 6 publications

References 6 publications

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase

Combined Application of Tacrolimus with Cyproconazole, Hymexazol and Novel {2-(3-R-1H-1,2,4-triazol-5-yl)phenyl}amines as Antifungals: In Vitro Growth Inhibition and In Silico Molecular Docking Analysis to Fungal Chitin Deacetylase

Inclusion Complexes of Hymexazol with Three Different Cucurbit[n]uril: Preparation, and Physicochemical and Antifungal Characterization

Determination of hymexazol in 26 foods of plant origin by modified QuEChERS method and liquid chromatography tandem-mass spectrometry

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