Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients

Garcı́a-Capdevila, L; López-Calull, C; Arroyo, Carmen M.; Moral, M.A; Mangues, María Antònia; Bonal, Joaquin

doi:10.1016/s0378-4347(96)00498-7

Cited by 51 publications

(45 citation statements)

References 6 publications

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“…The concentrations of imipenem were determined by reversedphase HPLC [6]. A 10 mL aliquot of the sample was injected onto a Nova-Pak C18 column (Waters Associates), using an automated injection system (Waters 717 plus Autosampler, Waters Associates).…”

Section: Imipenem Assaymentioning

confidence: 99%

Population pharmacokinetics and Monte Carlo dosing simulations of imipenem in patients with ventilator-associated pneumonia

Jaruratanasirikul¹,

Wongpoowarak²,

Nawakitrangson³

et al. 2017

Lung Breath J

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An alteration of pathophysiology in critically ill patients, resulting in pharmacokinetic change, are important factors in determining the therapeutic outcome of β-lactam antibiotics. The aims of this study were to reveal the population PK and assess the probability of target attainment (PTA) of imipenem in order to be able to optimize dosing recommendations for treatment of patients with VAP. Patients were randomized into two groups: Group I received a 0.5-h infusion of 0.5 g every 6 h (q6h) for nine doses and Group II received a 4-h infusion of 1 g q8h for seven doses. A Monte Carlo simulation was performed to determine the PTAs of achieving 20% T >MIC (exposure time during which the free drug concentration remains above the minimum inhibitory concentration (MIC)) and 40% T >MIC . The volume of distribution (Vd) and total clearance (CL) of imipenem were 15.89 L and 20.87 L/h, respectively. The high PTA (≥90%) achieving 40% fT >MIC for MICs of 4 μg/mL was observed when imipenem was administered by a 4-h infusion of 1 g q8h or 1 g q6h. These findings showed that the values of Vd and CL of imipenem in this patient population were greater than the values obtained from healthy subjects. A higher than recommended dosage regimen of imipenem may be required to optimize pharmacodynamic targets.

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Section: Imipenem Assaymentioning

confidence: 99%

Population pharmacokinetics and Monte Carlo dosing simulations of imipenem in patients with ventilator-associated pneumonia

Jaruratanasirikul¹,

Wongpoowarak²,

Nawakitrangson³

et al. 2017

Lung Breath J

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“…Blood samples (0.4 ml) were drawn from a central line independent of the line used to infuse the drug, immediately chilled, centrifuged at 4°C, stabilized, and stored at Ϫ80°C as described previously (10). Imipenem concentrations were determined by high-performance liquid chromatography (10).…”

mentioning

confidence: 99%

“…Imipenem concentrations were determined by high-performance liquid chromatography (10). Plasma was deproteinized by ultrafiltration (16), thus yielding the free fraction of the drug.…”

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confidence: 99%

Prospective Determination of Plasma Imipenem Concentrations in Critically Ill Children

Giannoni

Moreillon

Cotting

et al. 2006

Antimicrob Agents Chemother

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Plasma imipenem concentrations were measured in 19 critically ill children (median age, 0.8 year; range, 0.02 to 12.9 years). Wide interindividual variations (2 to 4؋ at peak and >10؋ at trough concentrations) resulted in unpredictable plasma levels in several children. To avoid subtherapeutic drug levels, we recommend treatment with at least 100 mg/kg of body weight/day of imipenem-cilastatin for critically ill children requiring such therapy.

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“…The level of excretion of vancomycin is similar to that of the aminoglycosides, but the CL-to-GFR ratio is smaller for vancomycin because of its higher level of protein binding in adults. Carbapenems (19) have a non-renal-related CL that is greater than the GFR (15,39). Studies with neonates have previously identified correlations between pharmacokinetic parameters and body weight (BW), PCA, gestational age (GA), postnatal age (PNA), and serum creatinine concentration (Cr).…”

mentioning

confidence: 99%

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

Kimura¹,

Sunakawa

Matsuura

et al. 2004

Antimicrob Agents Chemother

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Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients

Cited by 51 publications

References 6 publications

Population pharmacokinetics and Monte Carlo dosing simulations of imipenem in patients with ventilator-associated pneumonia

Population pharmacokinetics and Monte Carlo dosing simulations of imipenem in patients with ventilator-associated pneumonia

Prospective Determination of Plasma Imipenem Concentrations in Critically Ill Children

Population Pharmacokinetics of Arbekacin, Vancomycin, and Panipenem in Neonates

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