The objective of our study is to evaluate the concentration of radon ( 86 Rn) inside houses in the town of Koudougou in order to estimate its impact on the health of the population. Indeed, when uranium-rich minerals are found near the surface of the ground, radon concentrations can reach tens of becquerels per cubic meter in enclosed spaces. Given the nature of the geological base of Burkina Faso, this situation is quite probable and certain places that are sometimes poorly ventilated (house, school, office, etc.) can have radon levels high enough to constitute a health problem for occupants. Thus, twenty-four (24) sample houses were identified. In each house, the Corentium digital detector was between 0.8 m and 2 m for at least one week in a place where the occupants estimate that they spend more time of time and measure the concentration of radon in the long term and short term. The recorded data allowed us to determine the Absorbed Dose and the Annual Effective Dose of radon gas for each house in order to estimate the Risk of Cancer and the probable Number of Cases of Lung Cancer per million inhabitants. Thus, the results indicate that the long-term radon concentration varies between 6 Bq/m 3 and 285 Bq/m 3 respectively in houses 11 and 4 compared to 1 Bq/m 3 to 208 Bq/m 3 in the short term in the same houses. Also, in the long term, in control houses 1, 3 and 4, the radon level is above the recommended threshold interval. For the short term, these are houses 1, 3, 4 and 17 respectively with 110 Bq/m 3 , 142 Bq/m 3 , 208 Bq/m 3 and 105 Bq/m 3 . As for the long-term and short-term effective doses, only houses 1, 3, 4, 17 and 24 have values between 3 -10 Sv/year. The estimation of the relative risk of lung cancer gives How to cite this paper: