Determination of Intrinsic Dissolution Rate Using Miniaturized Rotating and Stationary Disk Systems

Tseng, Yin‐Chao; Patel, Mita; Zhao, Youna

doi:10.14227/dt210214p24

Cited by 14 publications

(6 citation statements)

References 12 publications

(12 reference statements)

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“…The compounds were tested both in powder form (compressed into pellets for rotating disk dissolution) and in film form. The intrinsic dissolution rate (IDR) of the films was compared to the dissolution rate of powder compressed into 1.57 mm diameter pellets of ~4 mm thickness 47 (Supplementary Fig. 10b ), while the printed films comprised 9 mm diameter circles on borosilicate glass disks (Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

Printing of small molecular medicines from the vapor phase

et al. 2017

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There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. The demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.

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Section: Resultsmentioning

confidence: 99%

Printing of small molecular medicines from the vapor phase

et al. 2017

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“…The intrinsic dissolution rate (IDR) measurement in the early drug discovery process was evaluated using a miniaturized stationary disk system (MSDS) and a miniaturized rotating disk system (MRDS) (Tseng, Patel, & Zhao, 2014). Chloramphenicol was used to evaluate these two apparatuses as a model drug with sample sizes of 3-10 mg.…”

Section: Rotating Disk Reactormentioning

confidence: 99%

“…Figure 13. Miniaturized stationary disk system, miniaturized rotating disk system, and Wood's rotating disk system (left to right) (Tseng et al, 2014) www.ccsenet.org/mas Modern Applied Science Vol. 10, No.…”

Section: Rotating Disk Reactormentioning

confidence: 99%

Rotating Disk Apparatus: Types, Developments and Future Applications

Rashed¹,

Abdulbari²,

Salleh³

et al. 2016

MAS

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Power consumption reduction investigations attracted the attention of enormous numbers of researchers in the past few decades due to its high academic and economic impacts. The pumping power losses during the transportation of crude oils are considered as one of the main power consuming applications due to the turbulent mode of transportation. Investigating the possible solutions for this problem is expensive and time consuming due to the large apparatuses needed to simulate the flow in real pipelines. Rotating disk apparatus (RDA) is an instrument mainly comprising a rotating disk and an electrical motor to rotate the disk, which was implemented as an efficient and economical path to simulate what can be done in pipelines through generating a controlled degree of turbulence. This technique was also used in many other scientific applications due to its dynamic mode of operation. For example, a rotating disk electrode was used in electrodeposition processes and to characterize deposition film thickness and uniformity. The rotating disk reactor was employed to investigate the reaction rate between fluids and solid surfaces. The present work evaluates the RDA from different prospective and applications in order to introduce it as an efficient research tools for future dynamic investigations.

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“…As particle size and shape would have an major impact on dissolution kinetics and potentially extent, we chose intrinsic dissolution testing as an area normalized characterization tool( Tseng et al, 2014 ). The IDR could be presumably affected by several different parameters such as preferred orientation, crystal habit, solubility, surface free energy ( SFE ) and crystal strains.…”

Section: Introductionmentioning

confidence: 99%

Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients

Ibraheem

Wagner

2021

International Journal of Pharmaceutics: X

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Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing process conditions. In this study, compaction of API under high pressure in the presence of hydrophilic excipients is proposed as a technique to improve the solubility and/or dissolution rate with an acceptable preservation of the supersaturation state. Binary mixtures of ibuprofen (IBU) with hydroxypropyl cellulose, isomalt, mannitol and sorbitol were compacted applying high pressure (500 MPa) with and without a previous co-milling step. Intrinsic dissolution rate (IDR) was selected to characterize and evaluate dissolution performance. The IDR of neat IBU increased from 5 to 88 fold and the aqueous solubility in the range of 3 to 54%. Regarding the polyols isomalt showed the highest impact on solubility and dissolution, without changing the crystallinity of IBU independent of a co-milling step. Even higher impact was achieved in combination with HPC. However, only without a previous co-milling step, ibuprofen remained crystalline, while co-milling induced an amorphous IBU-content of 38%. Based on XRPD and DSC findings, higher IDR and solubility values correlated with crystal modifications as well as IBU/excipient interactions.

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Determination of Intrinsic Dissolution Rate Using Miniaturized Rotating and Stationary Disk Systems

Cited by 14 publications

References 12 publications

Printing of small molecular medicines from the vapor phase

Printing of small molecular medicines from the vapor phase

Rotating Disk Apparatus: Types, Developments and Future Applications

Influence of high pressure compaction on solubility and intrinsic dissolution of ibuprofen binary mixtures employing standard excipients

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