Determination of ionization constants by conductimetry

Albert, Adrien; Serjeant, E. P.

doi:10.1007/978-94-009-5548-6_6

Cited by 83 publications

(109 citation statements)

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“…Such a value is slightly below the limit of our procedure and in reasonable agreement with our hypothesis. -Comparison of the Conformations of Disopyramide and Pheniramin-The significance of the evidence that an intramolecular hydrogen bond exists between the amido and pyridine groups of disopyramide in aqueous solution becomes clear when we compare the conformations of disopyramide with the probable conformations of the antihistaminic compound pheniramine (5).11 This drug molecule is structurally similar to disopyramide, as can be seen by comparing 5 with…”

Section: Resultsmentioning

confidence: 99%

Pharmacologically Active Conformation of Disopyramide: Evidence from Apparent pKa Measurements

Czeisler¹,

El-Rashidy²

1985

Journal of Pharmaceutical Sciences

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Section: Resultsmentioning

confidence: 99%

Pharmacologically Active Conformation of Disopyramide: Evidence from Apparent pKa Measurements

Czeisler¹,

El-Rashidy²

1985

Journal of Pharmaceutical Sciences

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“…The pK a values of all the functionalized oximes were determined spectrophotometricaly using a Thermofisher Evolution 300 UV-Visible spectrophotometer equipped with a temperature controller (Peltier) by using a well-known method of Albert and Sergeant. 29 It is based on direct determination of the ratio of protonated to deprotonated species in buffer solutions. An aliquot (3 mL) of a stock solution (5 × 10 -4 M) of functionalized oxime in triple-distilled water was diluted with a 25-mL phosphate buffer solution.…”

Section: Spectrophotometric Methodsmentioning

confidence: 99%

Micellar‐accelerated hydrolysis of organophosphate and thiophosphates by pyridine oximate

Kandpal

Dewangan

Nagwanshi³

et al. 2018

Int J of Chemical Kinetics

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Rate constants for the hydrolysis reaction of phosphate (paraoxon) and thiophosphate (parathion, fenitrothion) esters by oximate (pyridinealdoxime 2‐PyOx− and 4‐PyOx−) and its functionalized pyridinium surfactants 4‐(hydroxyimino) methyl)‐1‐alkylpyridinium bromide ions (alkyl = CnH2n+1, n = 10, 12, 14, 16) have been measured kinetically at pH 9.5 and 27°C in micellar media of cationic surfactants cetyltrimethylammonium bromide (CTAB) and cetylpyridinium bromide (CPB). Acid dissociation constant, pKa, of oximes has also been determined by spectrophotometric, kinetic, and potentiometric methods. The rate acceleration effects of cationic micelles have been explored. Cationic micelles of the pyridinium head group (CPB) showed a large catalytic effect than the ammonium head group (CTAB). The effects of pH, oximate concentration, and surfactants have been discussed.

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“…The value of log U H was found to be 0.48. The experimental procedures used for determination of the pK a values and for calculations using the computer program MINIQUAD75 were as previously described [26,27].…”

Section: Methods Bmentioning

confidence: 99%

A facile synthesis and tautomeric structure of novel 4‐arylhydrazono‐3‐(2‐hydroxyphenyl)‐2‐pyrazolin‐5‐ones and their application as disperse dyes

et al. 2013

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The main target of this paper was the synthesis of novel azo disperse dyes with better dyeing properties, together with a systematic investigation to determine their dominant tautomer(s) from 12 possible tautomeric structures. In this regard, novel azopyrazolin‐5‐one dyes were synthesised via the reaction of hydrazine hydrate with 2,3,4‐chromantrione‐3‐arylhydrazones. The acid dissociation constants both in the ground and in the excited state for the series prepared were determined and correlated by the Hammett equation. The results of this correlation, together with spectral data, indicated that the compounds under scrutiny exist predominantly in the keto‐hydrazo structure as a Z‐configuration, both in the ground and in the excited state. Finally, the synthesised dyes were applied as disperse dyes for dyeing polyester fabrics, and their fastness properties were evaluated. Also, the position of colour in CIELAB coordinates was estimated and discussed.

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Determination of ionization constants by conductimetry

Cited by 83 publications

References 0 publications

Pharmacologically Active Conformation of Disopyramide: Evidence from Apparent pKa Measurements

Pharmacologically Active Conformation of Disopyramide: Evidence from Apparent pKa Measurements

Micellar‐accelerated hydrolysis of organophosphate and thiophosphates by pyridine oximate

A facile synthesis and tautomeric structure of novel 4‐arylhydrazono‐3‐(2‐hydroxyphenyl)‐2‐pyrazolin‐5‐ones and their application as disperse dyes

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