Determination of Kinetics in Biphasic Recognition Chiral Extraction for Separation of Phenylsuccinic Acid Enantiomers

Abstract

This paper reports on the determination of the intrinsic kinetics in biphasic recognition chiral extraction of phenylsuccinic acid enantiomers (H 2 A) by L-IBTA and HP-b-CD in a modified Lewis cell. The two-phase homogeneous reaction model was selected, because there is a finite physical solubility of phenylsuccinic acid enantiomers in both the aqueous phase and the organic phase. The regime analysis was split up in three parts: a regime analysis on the aqueous phase reaction in the absence of organic phase reaction, a regime analysis of the organic phase reaction in the absence of the aqueous phase reaction, and a regime analysis of reactions in both phases. The reactions have been found to be first order with respect to H 2 A and second order with respect to L-IBTA and HP-b-CD. Competitive extraction of H 2 A enantiomers with HP-b-CD and L-IBTA has great influence on the extraction process. With increase of HP-b-CD concentration, high enantioselectivity was obtained, but the extraction rate decreases.