Determination of L-Ascorbic Acid in Pharmaceuticals by Using Chlorpromazine Hydrochloride as Oxidation-Reduction Indicator

Al-rikabi, A. M. K.; Al-jabri, F. M.; Al-mothefer, T. M.

doi:10.1080/00032719008052443

Cited by 7 publications

(1 citation statement)

References 20 publications

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“…A number of different types of voltammetric methods making use of a variety of electrodes have also been developed. [15][16][17][18] Most of the methods developed for ascorbic acid are visual and potentiometric titrants such as ceric ammonium sulphate, 19) N-chlorosuccinimide, 20) peroxymono sulphate, 21) hexacyanoferrate(III), 22) mercury(II) nitrate, 23) silver nitrate, 24) copper(II) sulphate, 25) codine 26) and N-bromosuccinimide. 27) The widely used British Pharmacopoeia (BP) method recommends visual titration of ascorbic acid 28) with cerium(IV).…”

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confidence: 99%

Indirect Potentiometric Titration of Ascorbic Acid in Pharmaceutical Preparations Using Copper Based Mercury Film Electrode

Nazer

Hameed

Riyazuddin

2004

CHEMICAL & PHARMACEUTICAL BULLETIN

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A simple and rapid potentiometric method for the estimation of ascorbic acid in pharmaceutical dosage forms has been developed. The method is based on treating ascorbic acid with iodine and titration of the iodide produced equivalent to ascorbic acid with silver nitrate using Copper Based Mercury Film Electrode (CBMFE) as an indicator electrode. Interference study was carried to check possible interference of usual excipients and other vitamins. The precision and accuracy of the method was assessed by the application of lack-of-fit test and other statistical methods. The results of the proposed method and British Pharmacopoeia method were compared using F and t-statistical tests of significance.

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