Landslide occurrence in Colombia is very frequent due to its geographical location in the Andean mountain range, with a very pronounced orography, a significant geological complexity and an outstanding climatic variability. More specifically, the study area around the Bogotá-Villavicencio road in the central sector of the Eastern Cordillera is one of the regions with the highest concentration of phenomena, which makes its study a priority. An inventory and detailed analysis of 2506 landslides has been carried out, in which five basic typologies have been differentiated: avalanches, debris flows, slides, earth flows and creeping areas. Debris avalanches and debris flows occur mainly in metamorphic materials (phyllites, schists and quartz-sandstones), areas with sparse vegetation, steep slopes and lower sections of hillslopes; meanwhile, slides, earth flows and creep occur in Cretaceous lutites, crop/grass lands, medium and low slopes and lower-middle sections of the hillslopes. Based on this analysis, landslide susceptibility models have been made for the different typologies and with different methods (matrix, discriminant analysis, random forest and neural networks) and input factors. The results are generally quite good, with average AUC-ROC values above 0.7–0.8, and the machine learning methods are the most appropriate, especially random forest, with a selected number of factors (between 6 and 8). The degree of fit (DF) usually shows relative errors lower than 5% and success higher than 90%. Finally, an integrated landslide susceptibility map (LSM) has been made for shallower and deeper types of movements. All the LSM show a clear zonation as a consequence of the geological control of the susceptibility.