2005
DOI: 10.1152/ajpheart.00934.2004
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Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling

Abstract: Preconditioned prepared strips (n ϭ 78) of segments from the midregion of the left anterior descending coronary artery from the individual layers in axial and circumferential directions were subjected to cyclic quasi-static uniaxial tension tests, and ultimate tensile stresses and stretches were documented. The ratio of outer diameter to total wall thickness was 0.189 Ϯ 0.014; ratios of adventitia, media, and intima thickness to total wall thickness were 0.4 Ϯ 0.03, 0.36 Ϯ 0.03, and 0.27 Ϯ 0.02, respectively; … Show more

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Cited by 842 publications
(861 citation statements)
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“…The thickness of each arterial layer was discretised by two elements and each layer was of equal thickness. This closely complied with the ratio of the thickness of adventitia, media, and intima which have been reported as 0.40 ± 0.03, 0.36 ± 0.03, and 0.27 ± 0.02, respectively in [10]. Six elements were assigned through the plaque thickness in the central region.…”
Section: Model Geometrysupporting
confidence: 84%
“…The thickness of each arterial layer was discretised by two elements and each layer was of equal thickness. This closely complied with the ratio of the thickness of adventitia, media, and intima which have been reported as 0.40 ± 0.03, 0.36 ± 0.03, and 0.27 ± 0.02, respectively in [10]. Six elements were assigned through the plaque thickness in the central region.…”
Section: Model Geometrysupporting
confidence: 84%
“…The material parameters c , 1 k and 2 k are usually determined in vitro by mechanical experiment for special specimens, such as segments (Holzapfel and Weizsäcker 1998;Holzapfel et al 2000) or strips (Holzapfel et al 2005a) of the aorta or the artery wall. A more recent investigation indicates the neo-Hookean strain energy function represented by the first term of Eq.…”
Section: The Constitutive Modelmentioning
confidence: 99%
“…The typical ultimate tensile stress (UTS) for PDMS ranges from 3.9 MPa to 10.8 MPa (Mata et al 2005), whereas the Young's elastic modulus (E) has a value of ∼0.75MPa (Unger et al 2000). The UTS and E of the blood vessels has values from 0.4 MPa to 1.4 MPa (Holzapfel et al 2005) and ∼2.5 MPa (Steiger et al 1989) respectively. The UTS and E is PDMS formulation dependent, by adjusting the ratio of the crosslinker (curing agent) and also the thickness of the wall, PDMS may be able to mimic more closely the geometric and structural properties of in vivo microvessels; 3. easy to replicate complex microvascular networks with submicron fidelity (McDonald et al 2002, Shevkoplyas et al 2003, Shin et al 2004, Lima 2007); 4. due to its spontaneous adhesion onto glass substrates, PDMS sealing does not need any complex bonding technique.…”
Section: Pdms Versus Glass Microchannelsmentioning
confidence: 99%