Determination of lead in blood by atomic absorption spectrometry with electrothermal atomisation

Shuttler, Ian L.; Delves, H. T.

doi:10.1039/an9861100651

Cited by 52 publications

(10 citation statements)

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“…Determination of Pb in Biological Samples-Blood samples were taken periodically from the tail artery, and blood Pb levels were determined by electrothermal atomic absorption spectroscopy against certified standards (39). For the determination of Pb in urine and feces, total outputs were collected over 2-day periods from each rat individually.…”

Section: Potentiometric Titrations and The Determination Of Ph In Aqumentioning

confidence: 99%

Monensin Mediates a Rapid and Selective Transport of Pb2+

Hamidinia¹,

Shimelis²,

Tan³

et al. 2002

Journal of Biological Chemistry

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The carboxylic acid ionophore monensin, known as an electroneutral Na ؉ ionophore, an anticoccidial agent, and a growth-promoting feed additive in agriculture, is shown to be highly efficient as an ionophore for Pb 2؉ and to be highly selective for Pb 2؉ compared with other divalent cations. Monensin transports Pb 2؉ by an electroneutral mechanism in which the complex PbMonOH is the transporting species. Electrogenic transport via the species PbMon ؉ may also be possible. Monensin catalyzed Pb 2؉ transport is little affected by Ca 2؉ , Mg 2؉ , or K ؉ concentrations that are encountered in living systems. Na ؉ is inhibitory, but its effectiveness at 100 mM does not exceed ϳ50%. The poor activity of monensin as an ionophore for divalent cations other than Pb 2؉ is consistent with the pattern of complex formation constants observed in the mixed solvent 80% methanol/water. This pattern also explains why Ca 2؉ , Mg 2؉ , and K ؉ are ineffective as inhibitors of Pb 2؉ transport, but it does not fully explain the actions of Na ؉ , where kinetic features of the transport mechanism may also be important. When given to rats at 100 ppm in feed together with Pb 2؉ at 100 ppm in drinking water, monensin reduces Pb accumulation in several organs and tissues. It also accelerates the excretion of Pb that was accumulated previously and produces this effect without depleting the organs of zinc or copper. Monensin, used alone or in combination with other agents, may be useful for the treatment of Pb intoxication.

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Section: Potentiometric Titrations and The Determination Of Ph In Aqumentioning

confidence: 99%

Monensin Mediates a Rapid and Selective Transport of Pb2+

Hamidinia¹,

Shimelis²,

Tan³

et al. 2002

Journal of Biological Chemistry

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“…Most have been based on ETAAS, mainly using the stabilised temperature platform furnace approach, which became the standard. An early landmark development was that of Shuttler and Delves 83 who produced a method suitable for epidemiological studies. They used a diluent containing NH 3 , NH 4 H 2 PO 4 and (NH 4 ) 2 H 2 EDTA and added O 2 at the ashing stage.…”

Section: Leadmentioning

confidence: 99%

Atomic Spectrometry Updates: A 25-year retrospective

Butler¹,

Evans²,

Fisher³

et al. 2010

J. Anal. At. Spectrom.

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“…Otherwise, there is a potential risk for the disc to raise (particularly for blank filter papers), which could lead to some high BG possibly owing to occlusion of the light beam. 43 After these aspects were corrected, the blood spots could be efficiently vaporized. The only negative effect detected was the deposition of a small, compact carbonaceous residue after vaporization of every sample.…”

Section: Pb Atomization Conditionsmentioning

confidence: 99%