Determination of low‐molecular‐mass quaternary ammonium compounds by capillary electrophoresis and hyphenation with mass spectrometry

Buchberger, Wolfgang; Schöftner, Rainer

doi:10.1002/elps.200305419

Cited by 12 publications

(11 citation statements)

References 54 publications

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“…A recent review by Buchberger and Schöftner [65] summarized the current status of CZE-MS for the analysis of several classes of quaternary ammonium compounds by CZE-MS. Analytes, such as aliphatic tetralkylammoniums, alkylbenzyldimethylammoniums, and anticholinergic ammoniums, may increase the sensitivity of these compounds by at least two orders of magnitude when compared to HPLC-MS with high efficiency. A range of ten of the eleven aliphatic carboxylic acids was separated using a polymer-coated capillary in 16 min after optimization of the CZE-MS parameters [66].…”

Section: Miscellaneous Organic Anion and Cation Analysesmentioning

confidence: 99%

Capillary electrophoresis‐mass spectrometry: Recent advances to the analysis of small achiral and chiral solutes

Shamsi

Miller

2004

Electrophoresis

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We describe here the state-of-the-art development of on-line capillary electrophoresis-mass spectrometry (CE-MS) over the last two years. Technological developments included are novel designs of new interfaces and ionization sources, new capillary coatings, buffers, and micelles as well as application of various modes of CE-MS published in the recent literature. The areas of CE-MS application in analysis of small achiral and chiral solutes are covered in sections that highlight the recent advances and possibilities of each mode of CE-MS. Application areas reviewed in this paper include achiral and chiral pharmaceuticals, agrochemicals, carbohydrates, and small peptides. The separation of enantiomers using micellar electrokinetic chromatography (MEKC)-MS with molecular micelles and capillary electrochromatography (CEC)-MS using pack tapered columns appears to provide good tolerance to electrospray stability for routine on-line CE-MS. These two modes seem to be very suitable for sensitive detection of chiral pharmaceuticals in biological samples, but their use will probably increase in the near future. Overall, it seems that one mode of CE-MS, in particular capillary zone electrophoresis (CZE)-MS, is now recognized as established technique for analysis of small charged solutes, but other modes, such as MEKC-MS and CEC-MS, are still within a period of development in terms of both MS-compatible pseudostationary phases and columns as well as applications.

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Section: Miscellaneous Organic Anion and Cation Analysesmentioning

confidence: 99%

Capillary electrophoresis‐mass spectrometry: Recent advances to the analysis of small achiral and chiral solutes

Shamsi

Miller

2004

Electrophoresis

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“…CE-MS has also found use in determination of quaternary ammonium ions [62]. The sensitivity attained was two orders of magnitude higher compared to direct and indirect UV absorbance detection.…”

Section: Msmentioning

confidence: 98%

An evaluation of the experimental approaches to detection of small ions in CE

2007

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This review points out some important trends in the development of the detection techniques for small ions in CE. On the basis of selected literature references it briefly discusses some general requirements on detection techniques in CE. Various optical measurements, mass spectrometric approaches and electrochemical detection techniques are dealt with. Some specific features of microchip CE separation and detection are pointed out and possibilities of dual detection are mentioned. The principal parameters of the above detection techniques are then briefly compared.

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“…The determination of quaternary ammonium ions by CE has been reviewed [101]. The analytes included tetraalkylammonium and alkylbenzyldimethylammonium compounds frequently used as antiseptic and antibacterial agents as well as in various household products, several plant growth regulators and herbicides, by-products in bile acid sequestrants, and a range of anticholinergic drugs.…”

Section: Quaternary Ammonium Ionsmentioning

confidence: 99%

Recent applications of capillary electrophoresis‐electrospray ionisation‐mass spectrometry in drug analysis

Smyth¹

2005

Electrophoresis

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A critical review of applications for the period 2000-2004, taken from the Web of Knowledge database, of the technique capillary electrophoresis-electrospray ionisation-mass spectrometry (CE-ESI-MS) in drug analysis is presented. The review is concerned with molecules of mass less than 500 Da, chosen according to selected structural classes in which they give ESI signals primarily as [M+H](+) ions although other ions, such as [M-H](-), [M+Na](+), and [M+NH(4)](+), are also reported. These structural classes are drugs with amine-containing side chains, drugs with N-containing saturated ring structures, 1,4-benzodiazepines, other heterocyclic hypnotics, carbohydrates, sulphonylureas, anthracyclines, sulphonamides, penicillins, cephalosporins, tetracyclines, nitrocatechols, steroids, flavonoids/polyphenols, cannabinols, and miscellaneous molecules. Details are given on the fragmentations, where available, that these ionic species exhibit in-source and in ion-trap, triple quadrupole, and time of flight-mass spectrometers. The review gives a critical evaluation of these recent CE-ESI-MS analytical methods in drug analysis. Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided. Potential applications of CE-MS to particular drugs or drug classes are also briefly discussed in the text.

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Determination of low‐molecular‐mass quaternary ammonium compounds by capillary electrophoresis and hyphenation with mass spectrometry

Cited by 12 publications

References 54 publications

Capillary electrophoresis‐mass spectrometry: Recent advances to the analysis of small achiral and chiral solutes

Capillary electrophoresis‐mass spectrometry: Recent advances to the analysis of small achiral and chiral solutes

An evaluation of the experimental approaches to detection of small ions in CE

Recent applications of capillary electrophoresis‐electrospray ionisation‐mass spectrometry in drug analysis

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