Determination of LY355703 in dog and mouse plasma by positive ion liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization

Berna, Michael J.; Shugert, R.; Mullen, J.H.

doi:10.1002/(sici)1096-9888(199802)33:2<138::aid-jms617>3.0.co;2-7

Cited by 9 publications

(1 citation statement)

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“…Berna, Shugert, & Mullen (1998) have exclusively described an assay for the determination of cryptophycin 52 (LY355703) in dog and mouse plasma by LC‐MS/MS. An LLOQ of 2.1 ng/mL was obtained from 100 μL samples volumes of either dog or mouse plasma, with a signal to noise ratio of ∼40.…”

Section: Antimitotic Agentsmentioning

confidence: 99%

Liquid chromatography‐mass spectrometry for the quantitative bioanalysis of anticancer drugs

Stokvis

Rosing

Beijnen

2004

Mass Spectrometry Reviews

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The monitoring of anticancer drugs in biological fluids and tissues is important during both pre‐clinical and clinical development and often in routine clinical use. Traditionally, liquid chromatography (LC) in combination with ultraviolet (UV), fluorescence, or electrochemical detection is employed for this purpose. The successful hyphenation of LC and mass spectrometry (MS), however, has dramatically changed this. MS detection provides better sensitivity and selectivity than UV detection and, in addition, is applicable to a significantly larger group of compounds than fluorescence or electrochemical detection. Therefore, LC‐MS has now become the method of first choice for the quantitative bioanalysis of many anticancer agents. There are still, however, a lot of new developments to be expected in this area, such as the introduction of more sensitive and robust mass spectrometers, high‐throughput analyses, and further optimization of the coupled LC systems. Many articles have appeared in this field in recent years and are reviewed here. We conclude that LC‐MS is an extremely powerful tool for the quantitative analysis of anticancer drugs in biological samples. © 2004 Wiley Periodicals, Inc., Mass Spec Rev 24:887–917, 2005

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Section: Antimitotic Agentsmentioning

confidence: 99%

Liquid chromatography‐mass spectrometry for the quantitative bioanalysis of anticancer drugs

Stokvis

Rosing

Beijnen

2004

Mass Spectrometry Reviews

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Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Liuu,

Damont,

Perret

et al. 2024

Mass Spectrometry Reviews

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Cyclodepsipeptides (CDPs) represent a huge family of chemically and structurally diverse molecules with a wide ability for molecular interactions. CDPs are cyclic peptide‐related natural products made up of both proteinogenic and nonproteinogenic amino acids linked by amide and ester bonds. The combined use of different analytical methods is required to accurately determine their integral structures including stereochemistry, thus allowing deeper insights into their often‐intriguing bioactivities and their possible usefulness. Our goal is to present the various methods developed to accurately characterize CDPs. Presently, Marfey's method and NMR (nuclear magnetic resonance) are still considered the best for characterizing CDP configuration. Nevertheless, electrospray‐high resolution tandem mass spectrometry (ESI‐HRMS/MS) is of great value for efficiently resolving CDP's composition and sequences. For instance, recent data shows that the fragmentation of cationized CDPs (e.g., [M + Li]+ and [M + Na]+) leads to selective cleavage of ester bonds and specific cationized product ions (b series) useful to get unprecedented sequence information. Thus, after a brief presentation of their structure, biological functions, and biosynthesis, we also provide a historic overview of these various analytical approaches as well as their advantages and limitations with a special emphasis on the emergence of methods based on HRMS/MS through recent fundamental works and applications.

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Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography–tandem mass spectrometry

Wang

Luo

2001

Journal of Chromatography A

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Determination of LY355703 in dog and mouse plasma by positive ion liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization

Cited by 9 publications

References 0 publications

Liquid chromatography‐mass spectrometry for the quantitative bioanalysis of anticancer drugs

Liquid chromatography‐mass spectrometry for the quantitative bioanalysis of anticancer drugs

Origin and characterization of cyclodepsipeptides: Comprehensive structural approaches with focus on mass spectrometry analysis of alkali‐cationized molecular species

Determination of scutellarin in Erigeron breviscapus extract by liquid chromatography–tandem mass spectrometry

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