Determination of melamine derivatives, melame, meleme, ammeline and ammelide by high-performance cation-exchange chromatography

Ono, Satoshi; Funato, Tatsuo; Inoue, Yasuhiko; Munechika, Tetsue; Yoshimura, Toshiaki; Morita, Hiroyuki; Rengakuji, Seiichi; Shimasaki, Choichiro

doi:10.1016/s0021-9673(98)00441-5

Cited by 51 publications

(24 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various techniques including HPLC-UV [10][11][12] or hydrophilic interaction liquid chromatography (HILIC)-UV [13], HPLC-MS [14][15][16][17][18][19][20][21][22][23][24], GC-MS [24][25][26], desorption ionization MS [27], CE [28][29][30], electrochemical method [31], etc., have been used to detect melamine or cyanuric acid. For the simultaneous determination of melamine and cyanuric acid, HPLC-MS [32] and MALDI-MS [33] were employed.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

Xia

Zhou

et al. 2010

J of Separation Science

View full text Add to dashboard Cite

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatographyelectrospray mass spectrometryA hydrophilic interaction liquid chromatography coupled to ESI-MS (HILIC/ESI-MS) method for the simultaneous determination of melamine and related compounds, i.e. ammeline, ammelide and cyanuric acid in foods was developed and validated. The separation was accomplished on a Venusil HILIC column with a mobile phase of acetonitrile 1 10 mM ammonium formate buffer solution at pH 3.5 (88:12, v/v) under isocratic elution mode. For the detection of the targets, the ESI probe worked in the positive and negative switching mode. For each compound, three ions were selected as qualitative ions to obtain high specificity, and the most abundant ion of each compound was selected for quantification to obtain high sensitivity. The target compounds were quantified using SIM with 15N3-melamine and 13C3-cyanuric acid being used as an internal standards in the positive and negative modes, respectively. Compared with RP separation mode, HILIC has merits such as high separation and anti-interference efficiency. The method validation including linearity, LOD, LOQ, precision and recovery proved that the method has merits such high sensitivity, specificity and simplicity versus the other methods reported in the literature.

show abstract

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

Xia

Zhou

et al. 2010

J of Separation Science

View full text Add to dashboard Cite

show abstract

“…[30] Several authors have described the determination of the surface properties of selected heptazine derivatives and their use as potential stationary phases for ion and gas chromatographic separations. [31,32] Last but not least, the UV absorption, luminescence and NLO properties of heptazine derivatives may be exploited for photo stabilizers (UV protection), sensitizers and emission. [8,24,25,27] All the compounds mentioned above are exclusively derived from the hydroxyl form of cyameluric acid.…”

Section: Introductionmentioning

confidence: 99%

The Tautomeric Forms of Cyameluric Acid Derivatives

El‐Gamel

Seyfarth

Wagler

et al. 2007

Chemistry A European J

View full text Add to dashboard Cite

The tautomerism of cyameluric acid C6N7O3H3 (1 a), cyamelurates and other heptazine derivatives has recently been studied by several theoretical investigations. In this experimental study we prepared stannyl and silyl derivatives of cyameluric acid (1 a): C6N7O3[Sn(C4H9)3]3 (3 a), C6N7O3[Sn(C2H5)3]3 (3 b), and C6N7O3[Si(CH3)3]3 (4). In order to investigate the structure of 1 a the mono- and dipotassium cyamelurate hydrates K(C6N7O3H2)2 H2O (5) and K2(C6N7O3H)1 H2O (6) were synthesized by UV/Vis-controlled titration of a potassium cyamelurate solution with aqueous hydrochloric acid. Compounds 3-6 were characterized by FTIR and solid-state NMR spectroscopy as well as simultaneous thermal analysis (TGA, DTA). The single crystal X-ray structures of the salts 5 and 6 show that the hydrogen atoms in both anions are localized on the peripheral nitrogen atoms. This indicates-in combination with the solid-state NMR studies-that the most stable tautomer of solid 1 a is the triketo form with C3h symmetry. However, derivatives of both the hydroxyl and the amido tautomers may be formed depending on the substituent atoms: The spectroscopic data and single crystal structures of compounds C6N7O3[Si(CH3)3]3 (4) and the solvate C6N7O3[Sn(C2H5)3]3C2H4Cl2 (3 b') show that the former is derived from the symmetric trihydroxy form of 1 a, while 3 b' crystallizes as a chain-like polymer, which contains the tin atoms as multifunctional building blocks, that is, bridging pentacoordinated Et3SnO2 and Et3SnON units as well as non-bridging four-coordinated Et3SnN units. The cyameluric nucleus is part of the polymeric chains of C6N7O3[Sn(C2H5)3]3C2H4Cl2 (3 b'), by the action of both tautomeric forms of cyameluric acid, the amide and the ester form.

show abstract

“…However, some of them were complicated and time-consuming. For example, in HPLC methods, additional extraction steps, such as liquid-liquid [4], liquid-solid extraction [5] at cation-exchange [14] or hydrophilic modes [6], were normally needed for clearance of interferents from complicated samples. Moreover, in some cases (like GC mode [6]- [8]), special sample treatments, such as derivatization, were demanded to obtain better separation.…”

Section: Introductionmentioning

confidence: 99%

Determination of Melamine in Quail Egg and Milk with Capillary Zone Electrophoresis

Yu¹,

Wei²,

Wang³

et al. 2014

AJAC

View full text Add to dashboard Cite

A capillary zone electrophoresis method was developed for determination of melamine in food samples, such as quail egg and milk products. The CE procedure was performed on fused silica capillary (41 cm × 75 μm I.D.) at 17 kV using pH3.1 60mmol/L phosphate buffer as run buffer and detecting at 200 nm. The proposed method showed good linearity (0.5 -10.0 μmol/L) and low LOD (0.5 μmol/L) with good reproducibility (RSD% was 2.4 and 3.2 for migration time and peak area respectively), which made it suitable for quantity control of the related food product.

show abstract

Determination of melamine derivatives, melame, meleme, ammeline and ammelide by high-performance cation-exchange chromatography

Cited by 51 publications

References 10 publications

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

Simultaneous determination of melamine and related compounds by hydrophilic interaction liquid chromatography–electrospray mass spectrometry

The Tautomeric Forms of Cyameluric Acid Derivatives

Determination of Melamine in Quail Egg and Milk with Capillary Zone Electrophoresis

Contact Info

Product

Resources

About