Determination of Mescaline in Hallucinogenic Cactaceae by Ion-Interaction HPLC.

Gennaro, M. C.; Gioannini, E.; Giacosa, D.; Siccardi, D.

doi:10.1080/00032719608002260

Cited by 7 publications

(3 citation statements)

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“…pachanoi (Britton & Rose) Albesiano & R. Kiesling, a Cactaceae native to the Andean slopes of Peru and other countries of South America. , This species was formerly known as Echinopsis pachanoi (Britton and Rose) Friedrich and Rowley or Trichocereus pachanoi and is also called San Pedro. It is the most used species for mescaline psychoactivity in rituals. ,, …”

Section: Resultsmentioning

confidence: 99%

“…It is the most used species for mescaline psychoactivity in rituals. 45,47,48 For this application, the harmful CH 2 Cl 2 could be replaced in the first LLE step, either by EtOAc or heptane, with no loss in extraction performance (Figure 2D). However, considering merely the extraction efficiency, CH 2 Cl 2 should be the selected solvent for the second LLE step, leading to an alkaloidenriched fraction.…”

Section: Journal Of Natural Productsmentioning

confidence: 99%

See 1 more Smart Citation

Toward a More Sustainable Sample Preparation in Phytochemistry: Case Studies in Four Subclasses of Alkaloids

Chibli,

de Lima,

Carneiro

et al. 2024

J. Nat. Prod.

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The fact that alkaloids are bases has been the most explored chemical feature of their extraction and purification procedures. The main drawback of these procedures is that they employ undesirable chemicals, with HCl and CH 2 Cl 2 probably being the most commonly employed chemicals in their subsequent steps. This work tested the hypothesis that advantages in recovery efficiency support this common practice. Experiments were conducted in three laboratories, monitoring the alkaloids harmine (1), boldine (2), vincamine (3), and mescaline (4) extracted from Banisteriopsis caapi, Peumus boldus, Vinca minor, and Trichocereus macrogonus var. pachanoi, respectively. The research demonstrated that HCl could be replaced with citric acid (CA) without loss or even better extraction performance. The recommended EtOAc could completely replace CH 2 Cl 2 in three out of four study cases and partially in the fourth case without harming the extraction efficiency. In addition, the alternative solvents tert-amyl methyl ether (TAME) and n-butyl acetate (BuOAc) could enhance the extraction of alkaloids. These results might incentivize natural products laboratories to consider sustainability more routinely, thus being closer to current practices in the pharmaceutical industry, which has been replacing solvents and processes with greener ones.

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Section: Resultsmentioning

confidence: 99%

Section: Journal Of Natural Productsmentioning

confidence: 99%

Toward a More Sustainable Sample Preparation in Phytochemistry: Case Studies in Four Subclasses of Alkaloids

Chibli,

de Lima,

Carneiro

et al. 2024

J. Nat. Prod.

View full text Add to dashboard Cite

show abstract

“…Bufotenine and a series of related bufadienolides were identified by GC/MS in the aphrodisiac "Love Stone" and the Chinese Medication "Chan Su" (342). Mescaline was determined in hallucinogenic Cactaceae by ion-interaction HPLC (343). Chemical analysis by IR, UV, and TLC of suspected Captagon tablets seized revealed that they often contained different ingredients which would induce effects similar to those of fenethylline (344).…”

Section: Drugs and Poisonsmentioning

confidence: 99%